Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism

Motohide Seki, Takayuki Ohara, Timothy J. Hearn, Alexander Frank, Viviane C.H. Da Silva, Camila Caldana, Alex A.R. Webb, Akiko Satake

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Arabidopsis plants store part of the carbon fixed by photosynthesis as starch to sustain growth at night. Two competing hypotheses have been proposed to explain this diel starch turnover based on either the measurement of starch abundance with respect to circadian time, or the sensing of sugars to feedback to the circadian oscillator to dynamically adjust the timing of starch turnover. We report a phase oscillator model that permitted derivation of the ideal responses of the circadian regulation of starch breakdown to maintain sucrose homeostasis. Testing the model predictions using a sugar-unresponsive mutant of Arabidopsis demonstrated that the dynamics of starch turnover arise from the circadian clock measuring and responding to the rate of change of cellular sucrose. Our theory and experiments suggest that starch turnover is controlled by the circadian clock acting as a dynamic homeostat responding to sucrose signals to maintain carbon homeostasis.

Original languageEnglish
Article number8305
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Arabidopsis
starch
sugars
metabolism
sucrose
circadian rhythm
homeostasis
carbon
photosynthesis
mutants
prediction
testing

All Science Journal Classification (ASJC) codes

  • General

Cite this

Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism. / Seki, Motohide; Ohara, Takayuki; Hearn, Timothy J.; Frank, Alexander; Da Silva, Viviane C.H.; Caldana, Camila; Webb, Alex A.R.; Satake, Akiko.

In: Scientific reports, Vol. 7, No. 1, 8305, 01.12.2017.

Research output: Contribution to journalArticle

Seki, Motohide ; Ohara, Takayuki ; Hearn, Timothy J. ; Frank, Alexander ; Da Silva, Viviane C.H. ; Caldana, Camila ; Webb, Alex A.R. ; Satake, Akiko. / Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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