Adjuvant mitomycin-c prolongs survival time of patients undergoing extensive en bloc resection of carcinoma of the stomach invading the adjacent organs

Daisuke Korenaga, Hideo Baba, Akihiro Watanabe, Masaru Haraguchi, Yoshihiro Kakeji, Hiroyuki Orita, Yoshihiko Maehara, Keizo Sugitmachi

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Abstract

We retrospectively examined the long-term results of adjuvant chemotherapy with mitomycin-C (MMC) in 50 patients with gastric carcinoma invading the adjacent organs. All patients underwent gastrectomy and en bloc multiple resection of the invaded organs, with the intent of a potential cure. Evidence of direct invasion was confirmed histo-logically. These patients were classified into 3 groups, according to the dose schedule of MMC: 12 received prolonged, intermittent administration of the drug, in a total dose of 40 mg or more (group A); 19 were given a bolus injection at the time of surgery and/or on the following day, in a total dose of less than 40 mg (group B), and 19 were given no anticancer drugs (group C). These 3 groups were comparable with regard to various prognostic factors. The 5-year survival rates were 50, 32 and 17% in groups A, B and C. respectively. There was a statistical difference in survival between groups A and C (p < 0.05). These results indicate that extensive en bloc resection plus intensive adjuvant chemotherapy prolong the survival time for those with gastric carcinoma invading the adjacent organs.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalPharmacology
Volume41
Issue number2
DOIs
Publication statusPublished - Jan 1 1990

All Science Journal Classification (ASJC) codes

  • Pharmacology

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    Korenaga, D., Baba, H., Watanabe, A., Haraguchi, M., Kakeji, Y., Orita, H., Maehara, Y., & Sugitmachi, K. (1990). Adjuvant mitomycin-c prolongs survival time of patients undergoing extensive en bloc resection of carcinoma of the stomach invading the adjacent organs. Pharmacology, 41(2), 107-112. https://doi.org/10.1159/000138705