Abstract
At the beginning, β-arrestin is believed to regulate desensitization of G protein-coupled receptors. However, it becomes apparent that β-arrestin is involved in not only regulation but also signal transduction by identification of many proteins interacting with β-arrestin. So far, the model of regulation and signaling of G protein-coupled receptor is built on β2-adrenergic receptor. However, this model does not apply to all G protein-coupled receptors. The differential regulation and signaling between β1- and β2-adrenergic receptors is presented.
Original language | English |
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Journal | Folia Pharmacologica Japonica |
Volume | 122 |
Issue number | SUPPL. 1 |
Publication status | Published - Dec 1 2003 |
All Science Journal Classification (ASJC) codes
- Pharmacology