Adult patient with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder: Chronic active EBV infection or de novo extranodal natural killer (NK)/T-cell lymphoma, nasal type?

Rie Ohtsuka, Yasunobu Abe, Eriko Sada, Junichi Kiyasu, Akiyo Ashikari, Motoaki Shiratsuchi, Junji Nishimura, Ryoichi Takayanagi, Koichi Ohshima

Research output: Contribution to journalArticle

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Abstract

Chronic active Epstein-Barr virus (EBV) infection, which is considered to be a childhood diseases, often develops into natural killer (NK) or T-cell lymphoma after recurrent infectious mononucleosis (IM)-like symptoms. We describe a 56-year-old woman who developed NK-cell lymphoma after 9 months of recurrent IM-like symptoms, The patient had an unusual anti-EBV antibody profile. Increased levels of EBV genome were detected in the liver and peripheral blood. Several chemotherapy regimens were ineffective, and the patent died of progression of lymphoma. Certain subtypes of NK-cell lymphoma showing a long-lasting prodrome related to chronic EBV infection may exist.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalInternal Medicine
Volume48
Issue number6
DOIs
Publication statusPublished - Jul 14 2009

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Natural Killer T-Cells
Epstein-Barr Virus Infections
Lymphoproliferative Disorders
T-Cell Lymphoma
Human Herpesvirus 4
Nose
Lymphoma
Infectious Mononucleosis
Natural Killer Cells
Genome
Drug Therapy
Antibodies
Liver

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Adult patient with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder : Chronic active EBV infection or de novo extranodal natural killer (NK)/T-cell lymphoma, nasal type? / Ohtsuka, Rie; Abe, Yasunobu; Sada, Eriko; Kiyasu, Junichi; Ashikari, Akiyo; Shiratsuchi, Motoaki; Nishimura, Junji; Takayanagi, Ryoichi; Ohshima, Koichi.

In: Internal Medicine, Vol. 48, No. 6, 14.07.2009, p. 471-474.

Research output: Contribution to journalArticle

Ohtsuka, Rie ; Abe, Yasunobu ; Sada, Eriko ; Kiyasu, Junichi ; Ashikari, Akiyo ; Shiratsuchi, Motoaki ; Nishimura, Junji ; Takayanagi, Ryoichi ; Ohshima, Koichi. / Adult patient with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder : Chronic active EBV infection or de novo extranodal natural killer (NK)/T-cell lymphoma, nasal type?. In: Internal Medicine. 2009 ; Vol. 48, No. 6. pp. 471-474.
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