Advance of genetics in multiple sclerosis

    Research output: Contribution to journalReview article

    Abstract

    Multiple sclerosis (MS) is characterized by temporal and spatial dissemination of demyelination in the central nervous system and the pathogenesis results from both genetic and environmental factors. Elaborate surveys have revealed familial accumulation of MS and provide unequivocal evidence that genetic factors contribute to the susceptibility. Family studies strongly suggest a polygenic model of inheritance explained by relatively common allelic variants. The major histocompatibility complex (MHC) in chromosome 6p21.3 has been identified as a genetic risk locus for MS from 1970s, but it was not until genome wide association studies (GWAS) were conducted in MS that genetic risks outside of MHC were identified. International collaboration and the development of new laboratory and analytical methods enabled detection of risk loci with comparably low effect size. Currently, more than 100 risk loci outside of MHC were identified. However, the heritability is not fully explained by the genetic risks that have been identified by GWAS. The knowledge of genetic effects on clinical phenotype is also incomplete.

    Original languageEnglish
    Pages (from-to)23-29
    Number of pages7
    JournalClinical and Experimental Neuroimmunology
    Volume6
    DOIs
    Publication statusPublished - Dec 1 2015

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    Multiple Sclerosis
    Major Histocompatibility Complex
    Genome-Wide Association Study
    Multifactorial Inheritance
    Genetic Loci
    Demyelinating Diseases
    Central Nervous System
    Chromosomes
    Phenotype

    All Science Journal Classification (ASJC) codes

    • Neuroscience (miscellaneous)
    • Immunology
    • Immunology and Microbiology (miscellaneous)
    • Clinical Neurology

    Cite this

    Advance of genetics in multiple sclerosis. / Matsushita, Takuya.

    In: Clinical and Experimental Neuroimmunology, Vol. 6, 01.12.2015, p. 23-29.

    Research output: Contribution to journalReview article

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    abstract = "Multiple sclerosis (MS) is characterized by temporal and spatial dissemination of demyelination in the central nervous system and the pathogenesis results from both genetic and environmental factors. Elaborate surveys have revealed familial accumulation of MS and provide unequivocal evidence that genetic factors contribute to the susceptibility. Family studies strongly suggest a polygenic model of inheritance explained by relatively common allelic variants. The major histocompatibility complex (MHC) in chromosome 6p21.3 has been identified as a genetic risk locus for MS from 1970s, but it was not until genome wide association studies (GWAS) were conducted in MS that genetic risks outside of MHC were identified. International collaboration and the development of new laboratory and analytical methods enabled detection of risk loci with comparably low effect size. Currently, more than 100 risk loci outside of MHC were identified. However, the heritability is not fully explained by the genetic risks that have been identified by GWAS. The knowledge of genetic effects on clinical phenotype is also incomplete.",
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