Advanced gastric carcinoma simulating early gastric carcinoma

Masaki Mori, Yosuke Adachi, Keizo Sugimachi, Kenjiro Nakamura, Shigekazu Kuroiwa, Munetomo Enjoji

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Eighty‐six cases of advanced gastric carcinoma simulating early gastric carcinoma were studied clinicopathologically. Cytophotometric DNA analysis was also performed in 33 cases. Most of these particular carcinomas were of the depressed type on gross inspection. Histologically, the tumors were of diffuse type in 60%. The rate of the carcinomas restricted to within the muscularis propria was 48% and high in comparison with those in conventional advanced gastric carcinomas. There were four main growth patterns: small invasion type (Type A, 43 cases), ulcer‐connected type (Type B, 19 cases), vessel permeation type (Type C, six cases), and diffusely infiltrative type (Type D, 13 cases). There was a relationship between growth patterns, lymph node metastasis, and prognosis: Types A and B had a small percentage of lymph node metastasis and a good prognosis, whereas Types C and D a high percentage and a poor prognosis. DNA analysis revealed that two thirds of the examined cases showed a low ploidy pattern. The DNA ploidy patterns were concerned with the tumor growth pattern: high‐ploidy cases were rarely seen in Types A and B yet were frequent in Types C and D. The 5‐year survival rate was 73%, but results were poor in cases of tumors with blood vessel permeation, in those with lymph node metastasis, in those with the Type D or C growth patterns, and in those with high DNA ploidy pattern. Since these carcinomas can be understaged endoscopically and by gross examination, a precise study of the surgically excised tissues will aid in making an accurate prognosis.

Original languageEnglish
Pages (from-to)1033-1040
Number of pages8
JournalCancer
Volume65
Issue number4
DOIs
Publication statusPublished - Feb 15 1990

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Stomach
Carcinoma
Ploidies
Lymph Nodes
DNA
Growth
Neoplasm Metastasis
Vascular Tissue Neoplasms
Dilatation and Curettage
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Advanced gastric carcinoma simulating early gastric carcinoma. / Mori, Masaki; Adachi, Yosuke; Sugimachi, Keizo; Nakamura, Kenjiro; Kuroiwa, Shigekazu; Enjoji, Munetomo.

In: Cancer, Vol. 65, No. 4, 15.02.1990, p. 1033-1040.

Research output: Contribution to journalArticle

Mori, M, Adachi, Y, Sugimachi, K, Nakamura, K, Kuroiwa, S & Enjoji, M 1990, 'Advanced gastric carcinoma simulating early gastric carcinoma', Cancer, vol. 65, no. 4, pp. 1033-1040. https://doi.org/10.1002/1097-0142(19900215)65:4<1033::AID-CNCR2820650432>3.0.CO;2-8
Mori, Masaki ; Adachi, Yosuke ; Sugimachi, Keizo ; Nakamura, Kenjiro ; Kuroiwa, Shigekazu ; Enjoji, Munetomo. / Advanced gastric carcinoma simulating early gastric carcinoma. In: Cancer. 1990 ; Vol. 65, No. 4. pp. 1033-1040.
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