Advanced hepatocellular carcinoma with distant metastases, successfully treated by a combination therapy of α-interferon and oral tegafur/uracil

Atsushi Miyamoto, Koji Umeshita, Masato Sakon, Hiroaki Nagano, Hidetoshi Eguchi, Shin Ichi Kishimoto, Keizo Dono, Shoji Nakamori, Mitsukazu Gotoh, Morito Monden

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Abstract

We report a case of advanced hepatocellular carcinoma (HCC), successfully treated by a combination therapy of α-interferon (IFN-α) and tegafur/uracil (UFT). A 44-year-old Japanese man who underwent a partial hepatectomy for HCC developed tumor recurrence in the liver 10 months after surgery. Transcatheter arterial chemoembolization (TAE) was performed twice within 7 months, but was ineffective. Later, multiple metastatic lesions appeared in the liver, lung and spine. Following the third TAE, a combination therapy of IFN-α (10 × 106 units, i.m., t.i.w.) and UFT (300 mg, p.o.d.) was started. The treatment resulted in a fall in serum PIVKA-II (protein induced by vitamin K antagonism) levels from 906 mAU to normal levels and a complete resolution of all lung nodules within 6 months. At the latest follow up 24 months after the initiation of combination treatment, the patient was working full-time and showed no evidence of tumor relapse. A combination therapy of IFN-α and UFT may be promising for the treatment of advanced HCC.

Original languageEnglish
Pages (from-to)1447-1451
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume15
Issue number12
DOIs
Publication statusPublished - Jan 1 2000

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Tegafur
Uracil
Interferons
Hepatocellular Carcinoma
Neoplasm Metastasis
Therapeutics
Recurrence
Lung
Vitamin K
Liver
Hepatectomy
Neoplasms
Spine
Serum

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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Advanced hepatocellular carcinoma with distant metastases, successfully treated by a combination therapy of α-interferon and oral tegafur/uracil. / Miyamoto, Atsushi; Umeshita, Koji; Sakon, Masato; Nagano, Hiroaki; Eguchi, Hidetoshi; Kishimoto, Shin Ichi; Dono, Keizo; Nakamori, Shoji; Gotoh, Mitsukazu; Monden, Morito.

In: Journal of Gastroenterology and Hepatology (Australia), Vol. 15, No. 12, 01.01.2000, p. 1447-1451.

Research output: Contribution to journalArticle

Miyamoto, Atsushi ; Umeshita, Koji ; Sakon, Masato ; Nagano, Hiroaki ; Eguchi, Hidetoshi ; Kishimoto, Shin Ichi ; Dono, Keizo ; Nakamori, Shoji ; Gotoh, Mitsukazu ; Monden, Morito. / Advanced hepatocellular carcinoma with distant metastases, successfully treated by a combination therapy of α-interferon and oral tegafur/uracil. In: Journal of Gastroenterology and Hepatology (Australia). 2000 ; Vol. 15, No. 12. pp. 1447-1451.
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