Advanced hepatocellular carcinoma with distant metastases, successfully treated by a combination therapy of α-interferon and oral tegafur/uracil

Atsushi Miyamoto, Koji Umeshita, Masato Sakon, Hiroaki Nagano, Hidetoshi Eguchi, Shin Ichi Kishimoto, Keizo Dono, Shoji Nakamori, Mitsukazu Gotoh, Morito Monden

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35 Citations (Scopus)

Abstract

We report a case of advanced hepatocellular carcinoma (HCC), successfully treated by a combination therapy of α-interferon (IFN-α) and tegafur/uracil (UFT). A 44-year-old Japanese man who underwent a partial hepatectomy for HCC developed tumor recurrence in the liver 10 months after surgery. Transcatheter arterial chemoembolization (TAE) was performed twice within 7 months, but was ineffective. Later, multiple metastatic lesions appeared in the liver, lung and spine. Following the third TAE, a combination therapy of IFN-α (10 × 106 units, i.m., t.i.w.) and UFT (300 mg, p.o.d.) was started. The treatment resulted in a fall in serum PIVKA-II (protein induced by vitamin K antagonism) levels from 906 mAU to normal levels and a complete resolution of all lung nodules within 6 months. At the latest follow up 24 months after the initiation of combination treatment, the patient was working full-time and showed no evidence of tumor relapse. A combination therapy of IFN-α and UFT may be promising for the treatment of advanced HCC.

Original languageEnglish
Pages (from-to)1447-1451
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume15
Issue number12
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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