Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution

T. Ikeda, S. Hayashi, N. Kamikawaji, T. Sasazuki, N. Shigematsu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the effect of chronic inflammatory foci in the upper respiratory tract and/or HLA class 2 antigens on the clinical course of sarcoidosis. Sarcoidosis resolved spontaneously in 6 of 27 (22 percent) patients with CTL and in 19 of 29 (66 percent) without CTL (p<0.01). The clinical course became favorable after TLT in 7 of 14 cases with CTL. Patients with HLA-DR9 and DRw8 showed the highest ratio of patients who had protracted clinical course; those with HLA-DR2, DR5 and DR6 showed the lowest; and those with HLA-DR4, DRw52 and DRw53 were between these levels. A high responsiveness to SCW antigens was seen more frequently in sarcoidosis patients with protracted clinical course. The high responsiveness to SCW antigens was related to HLA-DR4, DRw8, DR9 and DRw53 in sarcoidosis patients. HLA antigens, especially HLA-DR, modulate the immune response to inhaled antigenic agents. Immune response seemed to affect the clinical course of sarcoidosis.

Original languageEnglish
Pages (from-to)758-762
Number of pages5
JournalChest
Volume101
Issue number3
DOIs
Publication statusPublished - Jan 1 1992

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution'. Together they form a unique fingerprint.

  • Cite this

    Ikeda, T., Hayashi, S., Kamikawaji, N., Sasazuki, T., & Shigematsu, N. (1992). Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution. Chest, 101(3), 758-762. https://doi.org/10.1378/chest.101.3.758