Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution

T. Ikeda, S. Hayashi, N. Kamikawaji, Takehiko Sasazuki, N. Shigematsu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We examined the effect of chronic inflammatory foci in the upper respiratory tract and/or HLA class 2 antigens on the clinical course of sarcoidosis. Sarcoidosis resolved spontaneously in 6 of 27 (22 percent) patients with CTL and in 19 of 29 (66 percent) without CTL (p<0.01). The clinical course became favorable after TLT in 7 of 14 cases with CTL. Patients with HLA-DR9 and DRw8 showed the highest ratio of patients who had protracted clinical course; those with HLA-DR2, DR5 and DR6 showed the lowest; and those with HLA-DR4, DRw52 and DRw53 were between these levels. A high responsiveness to SCW antigens was seen more frequently in sarcoidosis patients with protracted clinical course. The high responsiveness to SCW antigens was related to HLA-DR4, DRw8, DR9 and DRw53 in sarcoidosis patients. HLA antigens, especially HLA-DR, modulate the immune response to inhaled antigenic agents. Immune response seemed to affect the clinical course of sarcoidosis.

Original languageEnglish
Pages (from-to)758-762
Number of pages5
JournalChest
Volume101
Issue number3
DOIs
Publication statusPublished - Jan 1 1992

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Tonsillitis
Sarcoidosis
HLA-DR4 Antigen
Antigens
HLA-DR6 Antigen
HLA-DR5 Antigen
HLA-DR2 Antigen
HLA-DR Antigens
HLA Antigens
Respiratory System

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ikeda, T., Hayashi, S., Kamikawaji, N., Sasazuki, T., & Shigematsu, N. (1992). Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution. Chest, 101(3), 758-762. https://doi.org/10.1378/chest.101.3.758

Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution. / Ikeda, T.; Hayashi, S.; Kamikawaji, N.; Sasazuki, Takehiko; Shigematsu, N.

In: Chest, Vol. 101, No. 3, 01.01.1992, p. 758-762.

Research output: Contribution to journalArticle

Ikeda, T, Hayashi, S, Kamikawaji, N, Sasazuki, T & Shigematsu, N 1992, 'Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution', Chest, vol. 101, no. 3, pp. 758-762. https://doi.org/10.1378/chest.101.3.758
Ikeda, T. ; Hayashi, S. ; Kamikawaji, N. ; Sasazuki, Takehiko ; Shigematsu, N. / Adverse effect of chronic tonsillitis on clinical course of sarcoidosis in relation to HLA distribution. In: Chest. 1992 ; Vol. 101, No. 3. pp. 758-762.
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