Abstract
The affected sib pair method to detect the effect of HLA-linked disease genes has been explained from a practical viewpoint. It is based on the assumption that HLA haplotypes as marker are used to trace the inheritance pattern of closely linked disease susceptibility genes. Looking at families in which two or more siblings had disease in question, the nonrandom zygotic assortment of HLA haplotypes would be a demonstration of disease gene. Application of affected sib pair method to Graves' disease had delineated that two genes, HLA-lined and Gm-linked, are responsible for manifestation of the disease as recessive inheritance with high penetrance.
| Original language | English |
|---|---|
| Pages (from-to) | 295-311 |
| Number of pages | 17 |
| Journal | The Japanese Journal of Human Genetics |
| Volume | 27 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 1 1982 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Genetics(clinical)
Cite this
Affected sib pair method for searching major gene in multifactorial disease. / Yasuda, Norikazu; Sasazuki, Takehiko.
In: The Japanese Journal of Human Genetics, Vol. 27, No. 4, 01.12.1982, p. 295-311.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Affected sib pair method for searching major gene in multifactorial disease
AU - Yasuda, Norikazu
AU - Sasazuki, Takehiko
PY - 1982/12/1
Y1 - 1982/12/1
N2 - The affected sib pair method to detect the effect of HLA-linked disease genes has been explained from a practical viewpoint. It is based on the assumption that HLA haplotypes as marker are used to trace the inheritance pattern of closely linked disease susceptibility genes. Looking at families in which two or more siblings had disease in question, the nonrandom zygotic assortment of HLA haplotypes would be a demonstration of disease gene. Application of affected sib pair method to Graves' disease had delineated that two genes, HLA-lined and Gm-linked, are responsible for manifestation of the disease as recessive inheritance with high penetrance.
AB - The affected sib pair method to detect the effect of HLA-linked disease genes has been explained from a practical viewpoint. It is based on the assumption that HLA haplotypes as marker are used to trace the inheritance pattern of closely linked disease susceptibility genes. Looking at families in which two or more siblings had disease in question, the nonrandom zygotic assortment of HLA haplotypes would be a demonstration of disease gene. Application of affected sib pair method to Graves' disease had delineated that two genes, HLA-lined and Gm-linked, are responsible for manifestation of the disease as recessive inheritance with high penetrance.
UR - http://www.scopus.com/inward/record.url?scp=0020439639&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020439639&partnerID=8YFLogxK
U2 - 10.1007/BF01900442
DO - 10.1007/BF01900442
M3 - Article
C2 - 6897841
AN - SCOPUS:0020439639
VL - 27
SP - 295
EP - 311
JO - Journal of Human Genetics
JF - Journal of Human Genetics
SN - 1434-5161
IS - 4
ER -