Affinity capillary electrophoresis using DNA conjugates.

Y. Ozaki, T. Ihara, Yoshiki Katayama, M. Maeda

    Research output: Contribution to journalArticlepeer-review


    An oligonucleotide ((dT)12)-immobilized capillary was prepared for the affinity capillary electrophoresis of DNA. Oligonucleotides ((dA)6 and (dT)6) which had the same chain length but had different base composition were separated in high resolution in the presence of Mg2+ ion. Whereas (dA)6 eluted slightly earlier than (dT)6 in a conventional polyacrylamide-coated capillary, the order of their mobilities was reversed in the (dT)12-modified system, suggesting the complementary hydrogen bondings between (dA)6 and the immobilized (dT)12.

    Original languageEnglish
    Pages (from-to)235-236
    Number of pages2
    JournalNucleic acids symposium series
    Issue number37
    Publication statusPublished - Jan 1 1997

    All Science Journal Classification (ASJC) codes

    • Medicine(all)


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