Affinity purification of multifunctional oligomeric ligands synthesized: Via controlled radical polymerization

Yu Hoshino, Shinnosuke Shimohara, Yusuke Wada, Masahiko Nakamoto, Yoshiko Miura

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Abiotic oligomeric ligands with a strong affinity for a target peptide sequence were isolated by affinity purification from a pool of 30-mer acrylic random ter-oligomers that were synthesized via a controlled radical polymerization process. Our results indicate that the oligomeric ligands with suitable sequence and/or stereochemical configurations for the target can be isolated from as-polymerized random co-polymers based on the affinity to the target. This process will be a powerful tool for the development of stable and inexpensive ligands that can be used to detect, neutralize and purify proteins with a target epitope sequence. This journal is

Original languageEnglish
Pages (from-to)5597-5601
Number of pages5
JournalJournal of Materials Chemistry B
Volume8
Issue number26
DOIs
Publication statusPublished - Jul 14 2020

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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