Age and sex-related differences in dose-dependent hemodynamic response to landiolol hydrochloride during general anesthesia

Ju Mizuno, Ikuto Yoshiya, Takeshi Yokoyama, Yoshitsugu Yamada, Hideko Arita, Kazuo Hanaoka

Research output: Contribution to journalArticle

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Abstract

Objective: Landiolol hydrochloride is a new ultra-short-acting β1-adrenergic receptor blocking agent that is used for patients with tachycardia during general anesthesia. The hemodynamic response to a β-adrenergic receptor blocking agent is generally dependent on the subject. In the present investigation we investigated the effects of age and sex on the hemodynamic response to different doses of landiolol. Methods: Following a persistence of tachycardia for more than 1 min, landiolol was infused at 0.03125, 0.0625 and 0.125 mg kg-1 min-1 for 1 min followed by 0.01, 0.02 and 0.04 mg kg-1min-1 for 10 min in groups L, M and H, respectively. Heart rate (HR), systolic (sBP) and diastolic blood pressure (dBP) were recorded each minute during the procedure. The respective changes were evaluated using logistic analysis with the equation Y(t) = p + (q - p) / [1 + exp {(4m / (q - p))(k - t)}], where p, q, m and k indicate the upper asymptote, lower asymptote, maximum slope and time at the maximum slope. Results: Parameters q and k for HR in group H were smaller than those in group L, whereas the parameters for sBP and dBP were unchanged among the three groups. Parameter q for HR in group H decreased with age of the patient. There was no significant difference in the landiolol-induced change in HR between males and females. Conclusion: The hemodynamic response to landiolol is reliably modeled by the logistic function, especially in terms of HR. Landiolol causes a rapid and dose-dependent decrease in HR, whereas landiolol-induced changes in sBP and dBP are independent of dose. The landiolol-induced decrease in HR becomes larger with aging, but shows no sex difference. The logistic model may be useful for studying hemodynamic responses to landiolol based on age and sex differences, and may allow development of an improved monitoring system. Implication statement: The logistic function reliably represents the hemodynamic responses to landiolol. Landiolol reduces HR rapidly and in a dose-dependentl manner whereas landiolol-induced changes in sBP and dBP are independent of dose. A larger decrease in HR is caused by landiolol in elderly patients, but there is no sex difference in the landiolol-induced change in HR.

Original languageEnglish
Pages (from-to)243-252
Number of pages10
JournalEuropean Journal of Clinical Pharmacology
Volume63
Issue number3
DOIs
Publication statusPublished - Mar 1 2007
Externally publishedYes

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Sex Characteristics
General Anesthesia
Hemodynamics
Heart Rate
Blood Pressure
Adrenergic Antagonists
landiolol
Tachycardia
Adrenergic Receptors
Logistic Models

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

Age and sex-related differences in dose-dependent hemodynamic response to landiolol hydrochloride during general anesthesia. / Mizuno, Ju; Yoshiya, Ikuto; Yokoyama, Takeshi; Yamada, Yoshitsugu; Arita, Hideko; Hanaoka, Kazuo.

In: European Journal of Clinical Pharmacology, Vol. 63, No. 3, 01.03.2007, p. 243-252.

Research output: Contribution to journalArticle

Mizuno, Ju ; Yoshiya, Ikuto ; Yokoyama, Takeshi ; Yamada, Yoshitsugu ; Arita, Hideko ; Hanaoka, Kazuo. / Age and sex-related differences in dose-dependent hemodynamic response to landiolol hydrochloride during general anesthesia. In: European Journal of Clinical Pharmacology. 2007 ; Vol. 63, No. 3. pp. 243-252.
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abstract = "Objective: Landiolol hydrochloride is a new ultra-short-acting β1-adrenergic receptor blocking agent that is used for patients with tachycardia during general anesthesia. The hemodynamic response to a β-adrenergic receptor blocking agent is generally dependent on the subject. In the present investigation we investigated the effects of age and sex on the hemodynamic response to different doses of landiolol. Methods: Following a persistence of tachycardia for more than 1 min, landiolol was infused at 0.03125, 0.0625 and 0.125 mg kg-1 min-1 for 1 min followed by 0.01, 0.02 and 0.04 mg kg-1min-1 for 10 min in groups L, M and H, respectively. Heart rate (HR), systolic (sBP) and diastolic blood pressure (dBP) were recorded each minute during the procedure. The respective changes were evaluated using logistic analysis with the equation Y(t) = p + (q - p) / [1 + exp {(4m / (q - p))(k - t)}], where p, q, m and k indicate the upper asymptote, lower asymptote, maximum slope and time at the maximum slope. Results: Parameters q and k for HR in group H were smaller than those in group L, whereas the parameters for sBP and dBP were unchanged among the three groups. Parameter q for HR in group H decreased with age of the patient. There was no significant difference in the landiolol-induced change in HR between males and females. Conclusion: The hemodynamic response to landiolol is reliably modeled by the logistic function, especially in terms of HR. Landiolol causes a rapid and dose-dependent decrease in HR, whereas landiolol-induced changes in sBP and dBP are independent of dose. The landiolol-induced decrease in HR becomes larger with aging, but shows no sex difference. The logistic model may be useful for studying hemodynamic responses to landiolol based on age and sex differences, and may allow development of an improved monitoring system. Implication statement: The logistic function reliably represents the hemodynamic responses to landiolol. Landiolol reduces HR rapidly and in a dose-dependentl manner whereas landiolol-induced changes in sBP and dBP are independent of dose. A larger decrease in HR is caused by landiolol in elderly patients, but there is no sex difference in the landiolol-induced change in HR.",
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T1 - Age and sex-related differences in dose-dependent hemodynamic response to landiolol hydrochloride during general anesthesia

AU - Mizuno, Ju

AU - Yoshiya, Ikuto

AU - Yokoyama, Takeshi

AU - Yamada, Yoshitsugu

AU - Arita, Hideko

AU - Hanaoka, Kazuo

PY - 2007/3/1

Y1 - 2007/3/1

N2 - Objective: Landiolol hydrochloride is a new ultra-short-acting β1-adrenergic receptor blocking agent that is used for patients with tachycardia during general anesthesia. The hemodynamic response to a β-adrenergic receptor blocking agent is generally dependent on the subject. In the present investigation we investigated the effects of age and sex on the hemodynamic response to different doses of landiolol. Methods: Following a persistence of tachycardia for more than 1 min, landiolol was infused at 0.03125, 0.0625 and 0.125 mg kg-1 min-1 for 1 min followed by 0.01, 0.02 and 0.04 mg kg-1min-1 for 10 min in groups L, M and H, respectively. Heart rate (HR), systolic (sBP) and diastolic blood pressure (dBP) were recorded each minute during the procedure. The respective changes were evaluated using logistic analysis with the equation Y(t) = p + (q - p) / [1 + exp {(4m / (q - p))(k - t)}], where p, q, m and k indicate the upper asymptote, lower asymptote, maximum slope and time at the maximum slope. Results: Parameters q and k for HR in group H were smaller than those in group L, whereas the parameters for sBP and dBP were unchanged among the three groups. Parameter q for HR in group H decreased with age of the patient. There was no significant difference in the landiolol-induced change in HR between males and females. Conclusion: The hemodynamic response to landiolol is reliably modeled by the logistic function, especially in terms of HR. Landiolol causes a rapid and dose-dependent decrease in HR, whereas landiolol-induced changes in sBP and dBP are independent of dose. The landiolol-induced decrease in HR becomes larger with aging, but shows no sex difference. The logistic model may be useful for studying hemodynamic responses to landiolol based on age and sex differences, and may allow development of an improved monitoring system. Implication statement: The logistic function reliably represents the hemodynamic responses to landiolol. Landiolol reduces HR rapidly and in a dose-dependentl manner whereas landiolol-induced changes in sBP and dBP are independent of dose. A larger decrease in HR is caused by landiolol in elderly patients, but there is no sex difference in the landiolol-induced change in HR.

AB - Objective: Landiolol hydrochloride is a new ultra-short-acting β1-adrenergic receptor blocking agent that is used for patients with tachycardia during general anesthesia. The hemodynamic response to a β-adrenergic receptor blocking agent is generally dependent on the subject. In the present investigation we investigated the effects of age and sex on the hemodynamic response to different doses of landiolol. Methods: Following a persistence of tachycardia for more than 1 min, landiolol was infused at 0.03125, 0.0625 and 0.125 mg kg-1 min-1 for 1 min followed by 0.01, 0.02 and 0.04 mg kg-1min-1 for 10 min in groups L, M and H, respectively. Heart rate (HR), systolic (sBP) and diastolic blood pressure (dBP) were recorded each minute during the procedure. The respective changes were evaluated using logistic analysis with the equation Y(t) = p + (q - p) / [1 + exp {(4m / (q - p))(k - t)}], where p, q, m and k indicate the upper asymptote, lower asymptote, maximum slope and time at the maximum slope. Results: Parameters q and k for HR in group H were smaller than those in group L, whereas the parameters for sBP and dBP were unchanged among the three groups. Parameter q for HR in group H decreased with age of the patient. There was no significant difference in the landiolol-induced change in HR between males and females. Conclusion: The hemodynamic response to landiolol is reliably modeled by the logistic function, especially in terms of HR. Landiolol causes a rapid and dose-dependent decrease in HR, whereas landiolol-induced changes in sBP and dBP are independent of dose. The landiolol-induced decrease in HR becomes larger with aging, but shows no sex difference. The logistic model may be useful for studying hemodynamic responses to landiolol based on age and sex differences, and may allow development of an improved monitoring system. Implication statement: The logistic function reliably represents the hemodynamic responses to landiolol. Landiolol reduces HR rapidly and in a dose-dependentl manner whereas landiolol-induced changes in sBP and dBP are independent of dose. A larger decrease in HR is caused by landiolol in elderly patients, but there is no sex difference in the landiolol-induced change in HR.

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