Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation

X. Liu, Hiro Take, Yoshinori Hayashi, Hiroshi Nakanishi

Research output: Contribution to journalArticle

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Abstract

Chronic systemic inflammation induces age-dependent differential phenotypic changes in microglia and astrocytes, yielding an anti-inflammatory cell phenotype in young rats and a proinflammatory cell phenotype in middle-aged rats. These observations prompted further investigation of the functional outcomes of the resultant differential microglial phenotypic changes. The present study examined the effects of age-dependent differential microglial phenotypic changes following chronic systemic inflammation on the formation of the post-tetanic potentiation (PTP) and long-term potentiation (LTP) in the hippocampus. Microglia formed a proinflammatory cell phenotype to express ED1 and interleukin-1β (IL-1β) in the hippocampal CA1 region of middle-aged rats, but not in young rats following the establishment of adjuvant arthritis (AA). Furthermore, AA induced deficits in the formation of LTP in the Schaffer collateral-CA1 synapses of middle-aged rats, but not in young rats. On the other hand, the formation of PTP was impaired in both young and middle-aged AA rats. Minocycline, a known inhibitor of microglial activation, was systemically administered to middle-aged AA rats significantly restoring the mean magnitudes of both PTP and LTP. The mean expression levels of ED1 and IL-1β were significantly suppressed. These observations strongly suggest that chronic systemic inflammation induces deficits in the hippocampal LTP in middle-aged rats through neuroinflammation mainly induced by microglia.

Original languageEnglish
Pages (from-to)133-142
Number of pages10
JournalNeuroscience
Volume216
DOIs
Publication statusPublished - Aug 2 2012

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Long-Term Potentiation
Hippocampus
Inflammation
Experimental Arthritis
Microglia
Phenotype
Interleukin-1
Hippocampal CA1 Region
Minocycline
Astrocytes
Synapses
Anti-Inflammatory Agents

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation. / Liu, X.; Take, Hiro; Hayashi, Yoshinori; Nakanishi, Hiroshi.

In: Neuroscience, Vol. 216, 02.08.2012, p. 133-142.

Research output: Contribution to journalArticle

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