Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor ε1 subunit

Isao Ito, Kenji Sakimura, Masayoshi Mishina, Hiroyuki Sugiyama

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effects of targeted disruption of the N-methyl-D-aspartate (NMDA) receptor ε1 subunit gene were studied during the postnatal development of ε1-disrupted mutant mice. Using the mice at the ages of 2-3, 5-6 and 9-10 weeks, we examined NMDA receptor channel-mediated synaptic currents and long-term potentiation (LTP) in CA1 pyramidal neurons of hippocampal slices. NMDA receptor channel currents, expressed as the ratios to non-NMDA receptor channel currents, decreased with the age in both wild-type and mutant mice, but the values in the mutant mice were approximately half of those of the wild-type mice at all ages examined. The LTP in the mutant mice was also reduced, but in contrast to the NMDA receptor channel currents, the extent of the reduction in the LTP was age-dependent. The reduction was marginal at the age of 2-3 weeks, and became progressively prominent to adulthood, with the potentiation being 26% of that of the wild-type mice at 9-10 weeks.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalNeuroscience Letters
Volume203
Issue number1
DOIs
Publication statusPublished - Jan 12 1996

Fingerprint

Long-Term Potentiation
N-Methyl-D-Aspartate Receptors
D-Aspartic Acid
Pyramidal Cells
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor ε1 subunit. / Ito, Isao; Sakimura, Kenji; Mishina, Masayoshi; Sugiyama, Hiroyuki.

In: Neuroscience Letters, Vol. 203, No. 1, 12.01.1996, p. 69-71.

Research output: Contribution to journalArticle

Ito, Isao ; Sakimura, Kenji ; Mishina, Masayoshi ; Sugiyama, Hiroyuki. / Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor ε1 subunit. In: Neuroscience Letters. 1996 ; Vol. 203, No. 1. pp. 69-71.
@article{57ee50a4e9924a55bc496a73156203c5,
title = "Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor ε1 subunit",
abstract = "The effects of targeted disruption of the N-methyl-D-aspartate (NMDA) receptor ε1 subunit gene were studied during the postnatal development of ε1-disrupted mutant mice. Using the mice at the ages of 2-3, 5-6 and 9-10 weeks, we examined NMDA receptor channel-mediated synaptic currents and long-term potentiation (LTP) in CA1 pyramidal neurons of hippocampal slices. NMDA receptor channel currents, expressed as the ratios to non-NMDA receptor channel currents, decreased with the age in both wild-type and mutant mice, but the values in the mutant mice were approximately half of those of the wild-type mice at all ages examined. The LTP in the mutant mice was also reduced, but in contrast to the NMDA receptor channel currents, the extent of the reduction in the LTP was age-dependent. The reduction was marginal at the age of 2-3 weeks, and became progressively prominent to adulthood, with the potentiation being 26{\%} of that of the wild-type mice at 9-10 weeks.",
author = "Isao Ito and Kenji Sakimura and Masayoshi Mishina and Hiroyuki Sugiyama",
year = "1996",
month = "1",
day = "12",
doi = "10.1016/0304-3940(95)12258-3",
language = "English",
volume = "203",
pages = "69--71",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Age-dependent reduction of hippocampal LTP in mice lacking N-methyl-D-aspartate receptor ε1 subunit

AU - Ito, Isao

AU - Sakimura, Kenji

AU - Mishina, Masayoshi

AU - Sugiyama, Hiroyuki

PY - 1996/1/12

Y1 - 1996/1/12

N2 - The effects of targeted disruption of the N-methyl-D-aspartate (NMDA) receptor ε1 subunit gene were studied during the postnatal development of ε1-disrupted mutant mice. Using the mice at the ages of 2-3, 5-6 and 9-10 weeks, we examined NMDA receptor channel-mediated synaptic currents and long-term potentiation (LTP) in CA1 pyramidal neurons of hippocampal slices. NMDA receptor channel currents, expressed as the ratios to non-NMDA receptor channel currents, decreased with the age in both wild-type and mutant mice, but the values in the mutant mice were approximately half of those of the wild-type mice at all ages examined. The LTP in the mutant mice was also reduced, but in contrast to the NMDA receptor channel currents, the extent of the reduction in the LTP was age-dependent. The reduction was marginal at the age of 2-3 weeks, and became progressively prominent to adulthood, with the potentiation being 26% of that of the wild-type mice at 9-10 weeks.

AB - The effects of targeted disruption of the N-methyl-D-aspartate (NMDA) receptor ε1 subunit gene were studied during the postnatal development of ε1-disrupted mutant mice. Using the mice at the ages of 2-3, 5-6 and 9-10 weeks, we examined NMDA receptor channel-mediated synaptic currents and long-term potentiation (LTP) in CA1 pyramidal neurons of hippocampal slices. NMDA receptor channel currents, expressed as the ratios to non-NMDA receptor channel currents, decreased with the age in both wild-type and mutant mice, but the values in the mutant mice were approximately half of those of the wild-type mice at all ages examined. The LTP in the mutant mice was also reduced, but in contrast to the NMDA receptor channel currents, the extent of the reduction in the LTP was age-dependent. The reduction was marginal at the age of 2-3 weeks, and became progressively prominent to adulthood, with the potentiation being 26% of that of the wild-type mice at 9-10 weeks.

UR - http://www.scopus.com/inward/record.url?scp=0030053773&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030053773&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(95)12258-3

DO - 10.1016/0304-3940(95)12258-3

M3 - Article

C2 - 8742049

AN - SCOPUS:0030053773

VL - 203

SP - 69

EP - 71

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -