Age-related differences in recovery from inhalational anesthesia: a retrospective study

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Abstract

Introduction: It is important to understand the anesthetic requirements of elderly patients. However, little is known about age-related recovery from inhalational anesthetics. In this retrospective study, we compared age-related differences in recovery from three inhalational anesthetics in elderly subjects. Methods: Patients were investigated as three age groups which can be defined as age ranges pediatric (< 15 years), adult (15–64 years), and elderly patients (> 65 years) under general anesthesia using inhalational anesthetics. Anesthesia and surgery times, drug end-tidal concentrations, the time to first movement, time to eye opening, body movement, extubation, and discharge were recorded. The data were analyzed using a Kruskal–Wallis test and Steel–Dwass multiple comparisons. Results: A total of 594 patients were included in the study. In inhalational anesthetics such as sevoflurane, isoflurane, or desflurane, recovery from general anesthesia was not significantly different among age groups (P > 0.05). In inhalational group, recovery was significantly 5–40% faster in desflurane group than in other inhalational anesthetics groups (P < 0.05). There were 20% faster recovery in pediatric and adult groups with desflurane than in elderly with desflurane group. Drug end-tidal inhalational concentrations in pediatric group were significantly higher than that in adult and elderly groups of all inhalational anesthetics, respectively (P < 0.05). Conclusion: In the current study, we have found that recovery from desflurane was faster in younger patients than in other inhalational anesthetics and aged patients.

Original languageEnglish
Pages (from-to)1523-1527
Number of pages5
JournalAging Clinical and Experimental Research
Volume30
Issue number12
DOIs
Publication statusPublished - Dec 1 2018

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Anesthetics
Anesthesia
Retrospective Studies
Pediatrics
General Anesthesia
Age Groups
Isoflurane
Pharmaceutical Preparations
desflurane

All Science Journal Classification (ASJC) codes

  • Ageing
  • Geriatrics and Gerontology

Cite this

Age-related differences in recovery from inhalational anesthesia : a retrospective study. / Tsukamoto, Masanori; Yamanaka, Hitoshi; Yokoyama, Takeshi.

In: Aging Clinical and Experimental Research, Vol. 30, No. 12, 01.12.2018, p. 1523-1527.

Research output: Contribution to journalArticle

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