Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection

Jun Hoyoshi, Yasuhiro Kishihara, Kumiko Ueno, Kouzaburo Yamaji, Yasunobu Kawakami, Norihiro Furusyo, Yasunori Sawayama, Seizaburo Kashiwagi

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Background: Interferon alfa is used widely for patients with chronic hepatitis C virus (HCV) infection. Little is known, however, of the relationship between patients' sex and the effectiveness of interferon alfa treatment in these patients. Methods: We treated 311 patients (199 men and 112 women) with human lymphoblastoid interferon (6 million units subcutaneously every day for 2 weeks and 3 times a week for 22 weeks) and observed them for an additional 6 months. Serum HCV RNA levels and genotype were tested by polymerase chain reaction before treatment. A liver biopsy was also done. For the purposes of this study, a complete response was defined as the elimination of HCV RNA for at least 6 months after the termination of treatment. Results: The rate of complete response was 27.1% for men and 24.1% for women. With multiple logistic regression analysis, the HCV RNA level (P<.001), genotype (P<.001), patients' sex (P<.05), and the interaction between sex and age were associated with a complete response to interferon alfa. The rate of complete response was 33.3% in men aged 39 years and younger, 25.0% in men aged 40 years and older, 75.0% in women aged 39 years and younger, and 15.6% in women aged 40 years and older. The odds ratio by group was 1.00, 0.72, 4.38, and 0.21, respectively. Conclusions: Our finding that women aged 39 years and younger are responsive to interferon alfa treatment suggests that hormonal activity, in particular the level of estrogen, may be associated with the sustained elimination of HCV.

Original languageEnglish
Pages (from-to)177-181
Number of pages5
JournalArchives of Internal Medicine
Volume158
Issue number2
DOIs
Publication statusPublished - Feb 5 1998

Fingerprint

Chronic Hepatitis C
Virus Diseases
Interferon-alpha
Hepacivirus
RNA
Genotype
Therapeutics
Estrogens
Logistic Models
Odds Ratio
Regression Analysis
Biopsy
Polymerase Chain Reaction
Liver
Serum

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Hoyoshi, J., Kishihara, Y., Ueno, K., Yamaji, K., Kawakami, Y., Furusyo, N., ... Kashiwagi, S. (1998). Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection. Archives of Internal Medicine, 158(2), 177-181. https://doi.org/10.1001/archinte.158.2.177

Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection. / Hoyoshi, Jun; Kishihara, Yasuhiro; Ueno, Kumiko; Yamaji, Kouzaburo; Kawakami, Yasunobu; Furusyo, Norihiro; Sawayama, Yasunori; Kashiwagi, Seizaburo.

In: Archives of Internal Medicine, Vol. 158, No. 2, 05.02.1998, p. 177-181.

Research output: Contribution to journalArticle

Hoyoshi, J, Kishihara, Y, Ueno, K, Yamaji, K, Kawakami, Y, Furusyo, N, Sawayama, Y & Kashiwagi, S 1998, 'Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection', Archives of Internal Medicine, vol. 158, no. 2, pp. 177-181. https://doi.org/10.1001/archinte.158.2.177
Hoyoshi, Jun ; Kishihara, Yasuhiro ; Ueno, Kumiko ; Yamaji, Kouzaburo ; Kawakami, Yasunobu ; Furusyo, Norihiro ; Sawayama, Yasunori ; Kashiwagi, Seizaburo. / Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection. In: Archives of Internal Medicine. 1998 ; Vol. 158, No. 2. pp. 177-181.
@article{b000203c4074479b803884bbfcc46632,
title = "Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection",
abstract = "Background: Interferon alfa is used widely for patients with chronic hepatitis C virus (HCV) infection. Little is known, however, of the relationship between patients' sex and the effectiveness of interferon alfa treatment in these patients. Methods: We treated 311 patients (199 men and 112 women) with human lymphoblastoid interferon (6 million units subcutaneously every day for 2 weeks and 3 times a week for 22 weeks) and observed them for an additional 6 months. Serum HCV RNA levels and genotype were tested by polymerase chain reaction before treatment. A liver biopsy was also done. For the purposes of this study, a complete response was defined as the elimination of HCV RNA for at least 6 months after the termination of treatment. Results: The rate of complete response was 27.1{\%} for men and 24.1{\%} for women. With multiple logistic regression analysis, the HCV RNA level (P<.001), genotype (P<.001), patients' sex (P<.05), and the interaction between sex and age were associated with a complete response to interferon alfa. The rate of complete response was 33.3{\%} in men aged 39 years and younger, 25.0{\%} in men aged 40 years and older, 75.0{\%} in women aged 39 years and younger, and 15.6{\%} in women aged 40 years and older. The odds ratio by group was 1.00, 0.72, 4.38, and 0.21, respectively. Conclusions: Our finding that women aged 39 years and younger are responsive to interferon alfa treatment suggests that hormonal activity, in particular the level of estrogen, may be associated with the sustained elimination of HCV.",
author = "Jun Hoyoshi and Yasuhiro Kishihara and Kumiko Ueno and Kouzaburo Yamaji and Yasunobu Kawakami and Norihiro Furusyo and Yasunori Sawayama and Seizaburo Kashiwagi",
year = "1998",
month = "2",
day = "5",
doi = "10.1001/archinte.158.2.177",
language = "English",
volume = "158",
pages = "177--181",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "2",

}

TY - JOUR

T1 - Age-related response to interferon alfa treatment in women vs men with chronic hepatitis C virus infection

AU - Hoyoshi, Jun

AU - Kishihara, Yasuhiro

AU - Ueno, Kumiko

AU - Yamaji, Kouzaburo

AU - Kawakami, Yasunobu

AU - Furusyo, Norihiro

AU - Sawayama, Yasunori

AU - Kashiwagi, Seizaburo

PY - 1998/2/5

Y1 - 1998/2/5

N2 - Background: Interferon alfa is used widely for patients with chronic hepatitis C virus (HCV) infection. Little is known, however, of the relationship between patients' sex and the effectiveness of interferon alfa treatment in these patients. Methods: We treated 311 patients (199 men and 112 women) with human lymphoblastoid interferon (6 million units subcutaneously every day for 2 weeks and 3 times a week for 22 weeks) and observed them for an additional 6 months. Serum HCV RNA levels and genotype were tested by polymerase chain reaction before treatment. A liver biopsy was also done. For the purposes of this study, a complete response was defined as the elimination of HCV RNA for at least 6 months after the termination of treatment. Results: The rate of complete response was 27.1% for men and 24.1% for women. With multiple logistic regression analysis, the HCV RNA level (P<.001), genotype (P<.001), patients' sex (P<.05), and the interaction between sex and age were associated with a complete response to interferon alfa. The rate of complete response was 33.3% in men aged 39 years and younger, 25.0% in men aged 40 years and older, 75.0% in women aged 39 years and younger, and 15.6% in women aged 40 years and older. The odds ratio by group was 1.00, 0.72, 4.38, and 0.21, respectively. Conclusions: Our finding that women aged 39 years and younger are responsive to interferon alfa treatment suggests that hormonal activity, in particular the level of estrogen, may be associated with the sustained elimination of HCV.

AB - Background: Interferon alfa is used widely for patients with chronic hepatitis C virus (HCV) infection. Little is known, however, of the relationship between patients' sex and the effectiveness of interferon alfa treatment in these patients. Methods: We treated 311 patients (199 men and 112 women) with human lymphoblastoid interferon (6 million units subcutaneously every day for 2 weeks and 3 times a week for 22 weeks) and observed them for an additional 6 months. Serum HCV RNA levels and genotype were tested by polymerase chain reaction before treatment. A liver biopsy was also done. For the purposes of this study, a complete response was defined as the elimination of HCV RNA for at least 6 months after the termination of treatment. Results: The rate of complete response was 27.1% for men and 24.1% for women. With multiple logistic regression analysis, the HCV RNA level (P<.001), genotype (P<.001), patients' sex (P<.05), and the interaction between sex and age were associated with a complete response to interferon alfa. The rate of complete response was 33.3% in men aged 39 years and younger, 25.0% in men aged 40 years and older, 75.0% in women aged 39 years and younger, and 15.6% in women aged 40 years and older. The odds ratio by group was 1.00, 0.72, 4.38, and 0.21, respectively. Conclusions: Our finding that women aged 39 years and younger are responsive to interferon alfa treatment suggests that hormonal activity, in particular the level of estrogen, may be associated with the sustained elimination of HCV.

UR - http://www.scopus.com/inward/record.url?scp=15144359118&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=15144359118&partnerID=8YFLogxK

U2 - 10.1001/archinte.158.2.177

DO - 10.1001/archinte.158.2.177

M3 - Article

C2 - 9448556

AN - SCOPUS:15144359118

VL - 158

SP - 177

EP - 181

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 2

ER -