Age-related spatial and nonspatial short-term memory in Cav2.1α1 mutant mice, Rolling Nagoya

Eiki Takahashi, Kimie Niimi, Chitoshi Itakura

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Aged heterozygous Rolling Nagoya mice carrying Cav2.1α1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1α1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances.

Original languageEnglish
Pages (from-to)241-245
Number of pages5
JournalBehavioural Brain Research
Volume204
Issue number1
DOIs
Publication statusPublished - Dec 1 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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