Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice

Makoto Takeuchi, Hiroyuki Miyazaki, Katsuku Mirokawa, Tenio Yokokura, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    Age‐related changes in T cell subsets were examined in intestinal intraepithelial lymphocytes (i‐IEL), which contain unique T cells differentiating extrathymically. In 2‐month‐old mice bred under conventional condition, i‐IEL consisted of a large number of CD4CD8α/α+ cells bearing either T cell receptor (TcR)α/β or TcRγ/δ and only a few CD4+CD8α cells. In aged mice (6 months old and 24 months old), unique CD4+CD8α/α+ i‐IEL bearing TcRα/β increased in number and conversely the proportion of TcRγ/δ+ i‐IEL was decreased. Such an increase in number of CD4+CD8α/α+ cells was detected in i‐IEL from aged (14‐months old) nude mice, but not in aged (14 months old) germ‐free mice, suggesting that a significant fraction of TcRα/β T cells such as CD4+CD8α+ i‐IEL can develop along an extrathymic pathway under the influence of intestinal microflora with age.

    Original languageEnglish
    Pages (from-to)1409-1411
    Number of pages3
    JournalEuropean Journal of Immunology
    Volume23
    Issue number6
    DOIs
    Publication statusPublished - Jan 1 1993

    Fingerprint

    T-Lymphocyte Subsets
    T-Cell Antigen Receptor
    Lymphocytes
    T-Lymphocytes
    Nude Mice
    Cell Count

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice. / Takeuchi, Makoto; Miyazaki, Hiroyuki; Mirokawa, Katsuku; Yokokura, Tenio; Yoshikai, Yasunobu.

    In: European Journal of Immunology, Vol. 23, No. 6, 01.01.1993, p. 1409-1411.

    Research output: Contribution to journalArticle

    Takeuchi, M, Miyazaki, H, Mirokawa, K, Yokokura, T & Yoshikai, Y 1993, 'Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice', European Journal of Immunology, vol. 23, no. 6, pp. 1409-1411. https://doi.org/10.1002/eji.1830230637
    Takeuchi, Makoto ; Miyazaki, Hiroyuki ; Mirokawa, Katsuku ; Yokokura, Tenio ; Yoshikai, Yasunobu. / Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice. In: European Journal of Immunology. 1993 ; Vol. 23, No. 6. pp. 1409-1411.
    @article{9386c703955a448ab613fd56e5124829,
    title = "Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice",
    abstract = "Age‐related changes in T cell subsets were examined in intestinal intraepithelial lymphocytes (i‐IEL), which contain unique T cells differentiating extrathymically. In 2‐month‐old mice bred under conventional condition, i‐IEL consisted of a large number of CD4−CD8α/α+ cells bearing either T cell receptor (TcR)α/β or TcRγ/δ and only a few CD4+CD8α− cells. In aged mice (6 months old and 24 months old), unique CD4+CD8α/α+ i‐IEL bearing TcRα/β increased in number and conversely the proportion of TcRγ/δ+ i‐IEL was decreased. Such an increase in number of CD4+CD8α/α+ cells was detected in i‐IEL from aged (14‐months old) nude mice, but not in aged (14 months old) germ‐free mice, suggesting that a significant fraction of TcRα/β T cells such as CD4+CD8α+ i‐IEL can develop along an extrathymic pathway under the influence of intestinal microflora with age.",
    author = "Makoto Takeuchi and Hiroyuki Miyazaki and Katsuku Mirokawa and Tenio Yokokura and Yasunobu Yoshikai",
    year = "1993",
    month = "1",
    day = "1",
    doi = "10.1002/eji.1830230637",
    language = "English",
    volume = "23",
    pages = "1409--1411",
    journal = "European Journal of Immunology",
    issn = "0014-2980",
    publisher = "Wiley-VCH Verlag",
    number = "6",

    }

    TY - JOUR

    T1 - Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice

    AU - Takeuchi, Makoto

    AU - Miyazaki, Hiroyuki

    AU - Mirokawa, Katsuku

    AU - Yokokura, Tenio

    AU - Yoshikai, Yasunobu

    PY - 1993/1/1

    Y1 - 1993/1/1

    N2 - Age‐related changes in T cell subsets were examined in intestinal intraepithelial lymphocytes (i‐IEL), which contain unique T cells differentiating extrathymically. In 2‐month‐old mice bred under conventional condition, i‐IEL consisted of a large number of CD4−CD8α/α+ cells bearing either T cell receptor (TcR)α/β or TcRγ/δ and only a few CD4+CD8α− cells. In aged mice (6 months old and 24 months old), unique CD4+CD8α/α+ i‐IEL bearing TcRα/β increased in number and conversely the proportion of TcRγ/δ+ i‐IEL was decreased. Such an increase in number of CD4+CD8α/α+ cells was detected in i‐IEL from aged (14‐months old) nude mice, but not in aged (14 months old) germ‐free mice, suggesting that a significant fraction of TcRα/β T cells such as CD4+CD8α+ i‐IEL can develop along an extrathymic pathway under the influence of intestinal microflora with age.

    AB - Age‐related changes in T cell subsets were examined in intestinal intraepithelial lymphocytes (i‐IEL), which contain unique T cells differentiating extrathymically. In 2‐month‐old mice bred under conventional condition, i‐IEL consisted of a large number of CD4−CD8α/α+ cells bearing either T cell receptor (TcR)α/β or TcRγ/δ and only a few CD4+CD8α− cells. In aged mice (6 months old and 24 months old), unique CD4+CD8α/α+ i‐IEL bearing TcRα/β increased in number and conversely the proportion of TcRγ/δ+ i‐IEL was decreased. Such an increase in number of CD4+CD8α/α+ cells was detected in i‐IEL from aged (14‐months old) nude mice, but not in aged (14 months old) germ‐free mice, suggesting that a significant fraction of TcRα/β T cells such as CD4+CD8α+ i‐IEL can develop along an extrathymic pathway under the influence of intestinal microflora with age.

    UR - http://www.scopus.com/inward/record.url?scp=0027295126&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0027295126&partnerID=8YFLogxK

    U2 - 10.1002/eji.1830230637

    DO - 10.1002/eji.1830230637

    M3 - Article

    C2 - 8099017

    AN - SCOPUS:0027295126

    VL - 23

    SP - 1409

    EP - 1411

    JO - European Journal of Immunology

    JF - European Journal of Immunology

    SN - 0014-2980

    IS - 6

    ER -