Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice

Makoto Tsuda, Tsutomu Suzuki, Miwa Misawa

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro- L-arginine (NOARG; 8 mg/kg) and N-nitro-L-arginine methyl aster (L-NAME; 100 mg/kg), but not with D-NAME. Furthermore, these NOS inhibitors also d ease the threshold for pentylenetetrazole-induced seizure. However, the threshold for caffeine-induced seizure was not affected by NOARG. These results suggest that the endogenous NO system may play an important role in the expression of seizure by GABA(A) receptor inhibitory agents (DMCM and PTZ).

Original languageEnglish
Pages (from-to)PL339-PL343
JournalLife Sciences
Issue number23
Publication statusPublished - May 2 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'Aggravation of DMCM-induced seizure by nitric oxide synthase inhibitors in mice'. Together they form a unique fingerprint.

Cite this