Aggregation feature of fluorine-substituted benzene rings and intermolecular C-H⋯f interaction: Crystal structure analyses of mono- and trifluoro-L-phenylalanines

In Yasuko, Shouitirou Kishima, Katsuhiko Minoura, Takeru Nose, Yasuyuki Shimohigashi, Toshimasa Ishida

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

X-Ray crystal structures of four different fluorine-substituted phenylalanines (two mono- and two tri-substitutions) were analyzed to investigate the effect of fluorine atom on the association pattern of benzene rings. Although respective structures showed similar molecular packing in such a way that the layers of hydrophobic benzene rings and hydrophilic amino/carboxyl groups were alternately running along a crystallographic axis, the association patterns of benzene rings were different depending on the substitution position and number of fluorine atoms. The general features could be that the partially displaced face-to-face interactions are increased with increase in the number of fluorine atoms, whereas the edge-to-face interactions are decreased. The C-H bond next to a fluorine-substituted carbon atom could serve as a donor of an intermolecular C-H⋯F hydrogen bond.

Original languageEnglish
Pages (from-to)1258-1263
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number11
DOIs
Publication statusPublished - Nov 1 2003

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Drug Discovery

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