Aggregation of DNA-tagged liposomes controllable by external stimuli

Mai Hiraki, Tatsuo Maruyama, Hiroshi Yamamura, Masahiro Goto

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides were tethered to the outer surface of liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands initiated the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. The aggregated liposomes were dissociated by restriction enzyme to produce the initial discrete liposomes and re-aggregated by ligase.

    Original languageEnglish
    Title of host publication54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
    Pages2211
    Number of pages1
    Volume54
    Edition1
    Publication statusPublished - 2005
    Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
    Duration: May 25 2005May 27 2005

    Other

    Other54th SPSJ Annual Meeting 2005
    CountryJapan
    CityYokohama
    Period5/25/055/27/05

    All Science Journal Classification (ASJC) codes

    • Engineering(all)

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