Aggregation of DNA-tagged liposomes controllable by external stimuli

Mai Hiraki, Tatsuo Maruyama, Hiroshi Yamamura, Masahiro Goto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Here we describe a novel strategy of liposome aggregation employing DNA-surfactant, in which the aggregation of liposomes can be reversibly controlled by enzyme stimuli and temperature. Single-stranded oligonucleotides were tethered to the outer surface of liposomes. Mixing of the DNA-tagged liposomes with ones bearing complementary DNA strands initiated the aggregation of liposomes. The liposomes were linked with each other via duplex DNA. The aggregated liposomes were dissociated by restriction enzyme to produce the initial discrete liposomes and re-aggregated by ligase.

Original languageEnglish
Title of host publication54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan
Pages2211
Number of pages1
Volume54
Edition1
Publication statusPublished - 2005
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: May 25 2005May 27 2005

Other

Other54th SPSJ Annual Meeting 2005
CountryJapan
CityYokohama
Period5/25/055/27/05

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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  • Cite this

    Hiraki, M., Maruyama, T., Yamamura, H., & Goto, M. (2005). Aggregation of DNA-tagged liposomes controllable by external stimuli. In 54th SPSJ Annual Meeting 2005 - Polymer Preprints, Japan (1 ed., Vol. 54, pp. 2211)