Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland

Hidetaka Yamamoto, Hideoki Uryu, Yuichi Segawa, Masazumi Tsuneyoshi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The presence of invasive micropapillary component has been reported to be associated with salivary duct carcinoma and poor outcomes. Herein is described a rare case of invasive micropapillary salivary duct carcinoma of the parotid gland in a 60-year-old man. The micropapillary component was approximately 70% of the area of the tumor. Squamous differentiation was focally seen adjacent to the micropapillary component. On immunohistochemistry the ordinary salivary duct carcinoma component was positive for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and HER2/neu, whereas both micropapillary and squamous components were negative for GCDFP-15 and AR. Immunohistochemical staining for D2-40 highlighted the lymph vessel invasion of tumor cells. This patient developed metastases in the lymph nodes of the neck, and also in the liver, lung, and brain. The lymph nodes and liver metastases had both ordinary salivary duct carcinoma and micropapillary components. The patient died of tumor 11 months after the initial surgical operation. The results support that the presence of micropapillary component is associated with more aggressive behavior of salivary duct carcinoma. It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor.

Original languageEnglish
Pages (from-to)322-326
Number of pages5
JournalPathology International
Volume58
Issue number5
DOIs
Publication statusPublished - May 1 2008

Fingerprint

Salivary Ducts
Parotid Gland
Carcinoma
Androgen Receptors
Neoplasms
Lymph Nodes
Neoplasm Metastasis
Proteins
Liver
Lymph
Differential Diagnosis
Neck
Immunohistochemistry
Staining and Labeling
Lung
Brain

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland. / Yamamoto, Hidetaka; Uryu, Hideoki; Segawa, Yuichi; Tsuneyoshi, Masazumi.

In: Pathology International, Vol. 58, No. 5, 01.05.2008, p. 322-326.

Research output: Contribution to journalArticle

Yamamoto, Hidetaka ; Uryu, Hideoki ; Segawa, Yuichi ; Tsuneyoshi, Masazumi. / Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland. In: Pathology International. 2008 ; Vol. 58, No. 5. pp. 322-326.
@article{59a369aa566b41d2a06aab2c3ca83f81,
title = "Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland",
abstract = "The presence of invasive micropapillary component has been reported to be associated with salivary duct carcinoma and poor outcomes. Herein is described a rare case of invasive micropapillary salivary duct carcinoma of the parotid gland in a 60-year-old man. The micropapillary component was approximately 70{\%} of the area of the tumor. Squamous differentiation was focally seen adjacent to the micropapillary component. On immunohistochemistry the ordinary salivary duct carcinoma component was positive for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and HER2/neu, whereas both micropapillary and squamous components were negative for GCDFP-15 and AR. Immunohistochemical staining for D2-40 highlighted the lymph vessel invasion of tumor cells. This patient developed metastases in the lymph nodes of the neck, and also in the liver, lung, and brain. The lymph nodes and liver metastases had both ordinary salivary duct carcinoma and micropapillary components. The patient died of tumor 11 months after the initial surgical operation. The results support that the presence of micropapillary component is associated with more aggressive behavior of salivary duct carcinoma. It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor.",
author = "Hidetaka Yamamoto and Hideoki Uryu and Yuichi Segawa and Masazumi Tsuneyoshi",
year = "2008",
month = "5",
day = "1",
doi = "10.1111/j.1440-1827.2008.02231.x",
language = "English",
volume = "58",
pages = "322--326",
journal = "Pathology International",
issn = "1320-5463",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland

AU - Yamamoto, Hidetaka

AU - Uryu, Hideoki

AU - Segawa, Yuichi

AU - Tsuneyoshi, Masazumi

PY - 2008/5/1

Y1 - 2008/5/1

N2 - The presence of invasive micropapillary component has been reported to be associated with salivary duct carcinoma and poor outcomes. Herein is described a rare case of invasive micropapillary salivary duct carcinoma of the parotid gland in a 60-year-old man. The micropapillary component was approximately 70% of the area of the tumor. Squamous differentiation was focally seen adjacent to the micropapillary component. On immunohistochemistry the ordinary salivary duct carcinoma component was positive for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and HER2/neu, whereas both micropapillary and squamous components were negative for GCDFP-15 and AR. Immunohistochemical staining for D2-40 highlighted the lymph vessel invasion of tumor cells. This patient developed metastases in the lymph nodes of the neck, and also in the liver, lung, and brain. The lymph nodes and liver metastases had both ordinary salivary duct carcinoma and micropapillary components. The patient died of tumor 11 months after the initial surgical operation. The results support that the presence of micropapillary component is associated with more aggressive behavior of salivary duct carcinoma. It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor.

AB - The presence of invasive micropapillary component has been reported to be associated with salivary duct carcinoma and poor outcomes. Herein is described a rare case of invasive micropapillary salivary duct carcinoma of the parotid gland in a 60-year-old man. The micropapillary component was approximately 70% of the area of the tumor. Squamous differentiation was focally seen adjacent to the micropapillary component. On immunohistochemistry the ordinary salivary duct carcinoma component was positive for gross cystic disease fluid protein-15 (GCDFP-15), androgen receptor (AR), and HER2/neu, whereas both micropapillary and squamous components were negative for GCDFP-15 and AR. Immunohistochemical staining for D2-40 highlighted the lymph vessel invasion of tumor cells. This patient developed metastases in the lymph nodes of the neck, and also in the liver, lung, and brain. The lymph nodes and liver metastases had both ordinary salivary duct carcinoma and micropapillary components. The patient died of tumor 11 months after the initial surgical operation. The results support that the presence of micropapillary component is associated with more aggressive behavior of salivary duct carcinoma. It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor.

UR - http://www.scopus.com/inward/record.url?scp=42549126894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42549126894&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1827.2008.02231.x

DO - 10.1111/j.1440-1827.2008.02231.x

M3 - Article

C2 - 18429833

AN - SCOPUS:42549126894

VL - 58

SP - 322

EP - 326

JO - Pathology International

JF - Pathology International

SN - 1320-5463

IS - 5

ER -