TY - JOUR
T1 - Aging and Senescence of Dental Pulp and Hard Tissues of the Tooth
AU - Maeda, Hidefumi
N1 - Funding Information:
This review was financially supported by a Grant-in-Aid for Scientific Research (Project No. JP17H01598) from the Japan Society for the Promotion of Science.
Publisher Copyright:
© Copyright © 2020 Maeda.
PY - 2020/11/30
Y1 - 2020/11/30
N2 - The ability to consume a meal using one’s own teeth influences an individual’s quality of life. In today’s global aging society, studying the biological changes in aging teeth is important to address this issue. A tooth includes three hard tissues (enamel, dentin, and cementum) and a soft tissue (dental pulp). With advancing age, these tissues become senescent; each tissue exhibits a unique senescent pattern. This review discusses the structural alterations of hard tissues, as well as the molecular and physiological changes in dental pulp cells and dental pulp stem cells during human aging. The significance of senescence in these cells remains unclear. Thus, there is a need to define the regulatory mechanisms of aging and senescence in these cells to aid in preservation of dental health.
AB - The ability to consume a meal using one’s own teeth influences an individual’s quality of life. In today’s global aging society, studying the biological changes in aging teeth is important to address this issue. A tooth includes three hard tissues (enamel, dentin, and cementum) and a soft tissue (dental pulp). With advancing age, these tissues become senescent; each tissue exhibits a unique senescent pattern. This review discusses the structural alterations of hard tissues, as well as the molecular and physiological changes in dental pulp cells and dental pulp stem cells during human aging. The significance of senescence in these cells remains unclear. Thus, there is a need to define the regulatory mechanisms of aging and senescence in these cells to aid in preservation of dental health.
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U2 - 10.3389/fcell.2020.605996
DO - 10.3389/fcell.2020.605996
M3 - Review article
AN - SCOPUS:85097550574
VL - 8
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
SN - 2296-634X
M1 - 605996
ER -