Aging-associated alteration of telomere length and subtelomeric status in female patients with Parkinson's disease

Toyoki Maeda, Jing Zhi Guan, Masamichi Koyanagi, Yoshihiro Higuchi, Naoki Makino

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A telomere is a repetitive DNA structure at chromosomal ends that stabilizes the chromosome structure and prevents harmful end-to-end recombinations. The telomere length of somatic cells becomes shorter with aging because of the "end replication problem." This telomere shortening is accelerated by pathophysiological conditions including daily mental stress. Living with Parkinson's disease (PD) causes physical and mental stress; therefore, the authors hypothesized that the telomere length of somatic cells was shortened excessively in patients with PD. In order to detect PD-associated somatic telomeric alterations, the telomere length and subtelomeric methylation status of peripheral leukocytes of PD patients were assessed by Southern blotting, using methylation-sensitive and -insensitive isoschizomers. The results demonstrated that the peripheral leukocytes of Japanese female patients with PD bore fewer long telomeres and a proportional increase of hypomethylated subtelomeres in short telomeres in comparison with the healthy controls. This study indicates that with the neurodegeneration associated with PD, telomeric and subtelomeric structural alterations occur. These structural telomere altertions most likely occur secondary to the acceleration of aging-associated telomeric changes and the accelerated loss of cells bearing short telomeres.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalJournal of Neurogenetics
Volume26
Issue number2
DOIs
Publication statusPublished - Jun 2012

All Science Journal Classification (ASJC) codes

  • Genetics
  • Cellular and Molecular Neuroscience

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