Aging rather than stress strongly influences amino acid metabolisms in the brain and genital organs of female mice

Momoko Kodaira, Mao Nagasawa, Takeshi Yamaguchi, Hiromi Ikeda, Kimie Minaminaka, Vishwajit Surchowdhury, Shinobu Yasuo, Mitsuhiro Furuse

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aging and stress affect quality of life, and proper nourishment is one of means of preventing this effect. Today, there is a focus on the amount of protein consumed by elderly people; however, changes in the amino acid metabolism of individuals have not been fully considered. In addition, the difference between average life span and healthy life years is larger in females than it is in males. To prolong the healthy life years of females, in the present study we evaluated the influence of stress and aging on metabolism and emotional behavior by comparing young and middle-aged female mice. After 28 consecutive days of immobilization stress, behavioral tests were conducted and tissue sampling was performed. The results showed that the body weight of middle-aged mice was severely lowered by stress, but emotional behaviors were hardly influenced by either aging or stress. Aging influenced changes in amino acid metabolism in the brain and increased various amino acid levels in the uterus and ovary. In conclusion, we found that aged mice were more susceptible to stress in terms of body-weight reduction, and that amino acid metabolisms in the brain and genital organs were largely influenced by aging rather than by stress.

Original languageEnglish
Pages (from-to)72-79
Number of pages8
JournalMechanisms of Ageing and Development
Volume162
DOIs
Publication statusPublished - Mar 1 2017

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Female Genitalia
Amino Acids
Brain
Body Weight
Genitalia
Exercise Test
Psychological Stress
Immobilization
Uterus
Weight Loss
Ovary
Quality of Life
Proteins

All Science Journal Classification (ASJC) codes

  • Ageing
  • Developmental Biology

Cite this

Aging rather than stress strongly influences amino acid metabolisms in the brain and genital organs of female mice. / Kodaira, Momoko; Nagasawa, Mao; Yamaguchi, Takeshi; Ikeda, Hiromi; Minaminaka, Kimie; Surchowdhury, Vishwajit; Yasuo, Shinobu; Furuse, Mitsuhiro.

In: Mechanisms of Ageing and Development, Vol. 162, 01.03.2017, p. 72-79.

Research output: Contribution to journalArticle

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