Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

Chriselle D. Braganza, Chihiro Motozono, Koh Hei Sonoda, Sho Yamasaki, Kensuke Shibata, Mattie S.M. Timmer, Bridget L. Stocker

Research output: Contribution to journalArticle

Abstract

Mucosal-associated invariant T (MAIT) are a subset of innate-like T cells that are activated by uracil ligands presented by MR1. For the first time, we demonstrate that changes to the 6-aminoalkyl chain on uracil agonist 5-OP-RU can determine agonistic or antagonistic MAIT cell activity. Insomuch, a simplified agonist with a functional profile similar to 5-OP-RU, and a new structural class of antagonist that exhibits similar activity to known MAIT cell antagonist Ac-6-FP, were identified. This journal is

Original languageEnglish
Pages (from-to)5291-5294
Number of pages4
JournalChemical Communications
Volume56
Issue number39
DOIs
Publication statusPublished - May 14 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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