Air Pollutant Exposure Within a Few Days of Delivery and Placental Abruption in Japan

Takehiro Michikawa, Seiichi Morokuma, Shin Yamazaki, Kotaro Fukushima, Kiyoko Kato, Hiroshi Nitta

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Placental abruption is an emergency obstetric complication. Although the etiology of abruption is not fully understood, acute stimuli, such as ischemia and/or inflammation, are associated with rupture of the decidual artery, resulting in placental separation. Ischemia and inflammation are acute biologic effects of air pollution. Using a case-crossover design, we tested the hypothesis that a short-term increase in exposure to air pollutants is a potential trigger of placental abruption. Methods: We received data for western Japan (Kyushu-Okinawa Districts) from the Japan Perinatal Registry Network database. From 2005 to 2010, 821 singleton pregnant women with placental abruption were identified. We assigned daily concentrations of air pollutants, including nitrogen dioxide (NO 2), suspended particulate matter, ozone, and sulfur dioxide (SO 2), from the nearest monitoring station to the respective delivery hospital of each woman. Because information on the onset day of abruption was not obtained, we assumed the case day to be 1 day before the day of delivery. Results: Exposure to NO 2 at 2 days' lag was associated with placental abruption (temperature adjusted odds ratio per 10 ppb increase = 1.4; 95% confidence interval = 1.1, 1.8). The association patterns were similar, when we restricted to participants who delivered by emergency cesarean (1.4, 1.1, 1.9), or who delivered after 35 weeks of gestation (1.4, 1.0, 2.0). There was no association with suspended particulate matter, ozone, or SO 2. Conclusions: We observed an association between NO 2 exposure at 2 days before the day of delivery and placental abruption in pregnant Japanese women.

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalEpidemiology
Volume28
Issue number2
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

Abruptio Placentae
Air Pollutants
Japan
Particulate Matter
Ozone
Pregnant Women
Emergencies
Ischemia
Inflammation
Nitrogen Dioxide
Sulfur Dioxide
Air Pollution
Cross-Over Studies
Obstetrics
Registries
Rupture
Arteries
Odds Ratio
Databases
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Epidemiology

Cite this

Air Pollutant Exposure Within a Few Days of Delivery and Placental Abruption in Japan. / Michikawa, Takehiro; Morokuma, Seiichi; Yamazaki, Shin; Fukushima, Kotaro; Kato, Kiyoko; Nitta, Hiroshi.

In: Epidemiology, Vol. 28, No. 2, 01.03.2017, p. 190-196.

Research output: Contribution to journalArticle

Michikawa, Takehiro ; Morokuma, Seiichi ; Yamazaki, Shin ; Fukushima, Kotaro ; Kato, Kiyoko ; Nitta, Hiroshi. / Air Pollutant Exposure Within a Few Days of Delivery and Placental Abruption in Japan. In: Epidemiology. 2017 ; Vol. 28, No. 2. pp. 190-196.
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