Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo

Toshihiro Sera, Hideo Yokota, Kentaro Uesugi, Naoto Yagi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We evaluated the airway distention during lung inflation of varying size in healthy and allergic-sensitised mice in vivo. Computed tomography (CT) images of healthy and ovalbumin-treated mice were acquired using a synchrotron in vivo CT system when lung pressures was 0 and 20cmH2O, and the morphometric distension (diameter, length, and volume) and the compliance of airway segments (to as small as ∼150μm internal diameter) were calculated. With respect to airway size, in healthy mice, the changes in airway diameter and compliance were larger in the small-airway group. In contrast, in allergic-sensitised mice, there were no significant differences in the changes in airway distension or compliance. Airway wall thickness in allergic-sensitised mice increased significantly in all airway groups, but the change was much larger in the small than in the large-airway group. Compared with healthy airways, the changes in diameter and airway compliance of the allergic-sensitised mice were significantly smaller in the small-airway group.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume185
Issue number3
DOIs
Publication statusPublished - Feb 1 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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