Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo

Toshihiro Sera, Hideo Yokota, Kentaro Uesugi, Naoto Yagi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We evaluated the airway distention during lung inflation of varying size in healthy and allergic-sensitised mice in vivo. Computed tomography (CT) images of healthy and ovalbumin-treated mice were acquired using a synchrotron in vivo CT system when lung pressures was 0 and 20cmH2O, and the morphometric distension (diameter, length, and volume) and the compliance of airway segments (to as small as ∼150μm internal diameter) were calculated. With respect to airway size, in healthy mice, the changes in airway diameter and compliance were larger in the small-airway group. In contrast, in allergic-sensitised mice, there were no significant differences in the changes in airway distension or compliance. Airway wall thickness in allergic-sensitised mice increased significantly in all airway groups, but the change was much larger in the small than in the large-airway group. Compared with healthy airways, the changes in diameter and airway compliance of the allergic-sensitised mice were significantly smaller in the small-airway group.

Original languageEnglish
Pages (from-to)639-646
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume185
Issue number3
DOIs
Publication statusPublished - Feb 1 2013
Externally publishedYes

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Economic Inflation
Lung
Compliance
Tomography
Synchrotrons
Ovalbumin
Pressure

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo. / Sera, Toshihiro; Yokota, Hideo; Uesugi, Kentaro; Yagi, Naoto.

In: Respiratory Physiology and Neurobiology, Vol. 185, No. 3, 01.02.2013, p. 639-646.

Research output: Contribution to journalArticle

Sera, Toshihiro ; Yokota, Hideo ; Uesugi, Kentaro ; Yagi, Naoto. / Airway distension during lung inflation in healthy and allergic-sensitised mice in vivo. In: Respiratory Physiology and Neurobiology. 2013 ; Vol. 185, No. 3. pp. 639-646.
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