Alaska pollack protein Decreases brain 3-methoxy-4-hydroxyphenylglycol levels in fasting chicks

Shozo Tomonaga, Fuminori Kawabata, Junki Yoshida, Yumi Ogino, Tomoko Tsuji, Mitsuhiro Furuse

Research output: Contribution to journalArticle

Abstract

Alaska pollack protein (APP) reduces serum triacylglycerol and body fat accumulation by the enhancement of basal energy expenditure through fast-twitch muscle hypertrophy in rats. However, the effects of APP on brain function have not yet been clarified. In the present study, we investigated the effects of orally administered APP on the brain levels of 3-methoxy-4-hydroxyphenylglycol (MHPG), which is a metabolite of norepinephrine (NE) and can be used as an index of NE activity, in fasting chicks. Fasting stress significantly decreased plasma glucose, uric acid, triacylglycerol, proline and ornithine while MHPG levels in the brain and plasma corticosterone concentration were not affected. APP dose-dependently decreased MHPG level in the diencephalon, telencephalon and optic lobe. Plasma uric acid, alanine, β-alanine, arginine, anserine, aspartate, asparagine, glycine, histidine, isoleucine, leucine, lysine, 1-methylhistidine, 3-methylhisitidine, ornithine, proline, taurine and valine were dose-dependently increased with the increase of APP. It has been reported that some of them are known to centrally reduce the stress-induced behaviors of chicks. These results suggest that orally administered APP could influence brain NE activity through increase in amino acids to protect against stress conditions.

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalJournal of Poultry Science
Volume49
Issue number3
DOIs
Publication statusPublished - Jan 1 2012

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Theragra chalcogramma
fasting
chicks
brain
norepinephrine
proteins
ornithine
uric acid
alanine
proline
triacylglycerols
anserine
optic lobe
taurine
asparagine
corticosterone
aspartic acid
isoleucine
dosage
valine

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology

Cite this

Alaska pollack protein Decreases brain 3-methoxy-4-hydroxyphenylglycol levels in fasting chicks. / Tomonaga, Shozo; Kawabata, Fuminori; Yoshida, Junki; Ogino, Yumi; Tsuji, Tomoko; Furuse, Mitsuhiro.

In: Journal of Poultry Science, Vol. 49, No. 3, 01.01.2012, p. 171-177.

Research output: Contribution to journalArticle

Tomonaga, Shozo ; Kawabata, Fuminori ; Yoshida, Junki ; Ogino, Yumi ; Tsuji, Tomoko ; Furuse, Mitsuhiro. / Alaska pollack protein Decreases brain 3-methoxy-4-hydroxyphenylglycol levels in fasting chicks. In: Journal of Poultry Science. 2012 ; Vol. 49, No. 3. pp. 171-177.
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