Alcohol has a dose-related effect on parasympathetic nerve activity during sleep

Yohei Sagawa, Hideaki Kondo, Namiko Matsubuchi, Takaubu Takemura, Hironobu Kanayama, Yoshihiko Kaneko, Takashi Kanbayashi, Yasuo Hishikawa, Tetsuo Shimizu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The aim of this study was to identify the acute effects of ethanol on the relationship between sleep and heart rate variability (HRV) during sleep. Methods: Ten healthy male university students were enrolled in this study. An alcoholic beverage was given to each subject at a dosage of 0 (control), 0.5 (low dose: LD), or 1.0g (high dose: HD) of pure ethanol/kg of body weight. All experiments were performed at 3-week intervals. On the day of the experiment, a Holter electrocardiogram was attached to the subject for a 24-hour period, and the subject was instructed to drink the above-described dosage of alcoholic beverage 100minutes before going to bed; polysomnography was then performed for 8hours. Power spectral analysis of the HRV was performed using the maximum entropy method, and the low- (LF: 0.04 to 0.15Hz) and high-frequency (HF: 0.15 to 0.4Hz) components along with LF/HF ratio were calculated. Results: As alcohol consumption increased, the heart rate increased and the spectral power of HRV measured at each frequency range decreased. Higher doses of ethanol also increased the LF/HF ratio compared with the measured ratio of the control group. Conclusions: Acute ethanol intake inhibits parasympathetic nerve activity and results in predominance of sympathetic nerve activity during sleep, in a dosage-dependent manner. The results of this study suggest that ethanol interferes with the restorative functions of sleep.

Original languageEnglish
Pages (from-to)2093-2100
Number of pages8
JournalAlcoholism: Clinical and Experimental Research
Volume35
Issue number11
DOIs
Publication statusPublished - Nov 1 2011

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Sleep
Ethanol
Alcohols
Heart Rate
Alcoholic Beverages
Maximum entropy methods
Polysomnography
Entropy
Electrocardiography
Alcohol Drinking
Spectrum analysis
Experiments
Body Weight
Students
Control Groups
Power (Psychology)
Alcoholic beverages

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Sagawa, Y., Kondo, H., Matsubuchi, N., Takemura, T., Kanayama, H., Kaneko, Y., ... Shimizu, T. (2011). Alcohol has a dose-related effect on parasympathetic nerve activity during sleep. Alcoholism: Clinical and Experimental Research, 35(11), 2093-2100. https://doi.org/10.1111/j.1530-0277.2011.01558.x

Alcohol has a dose-related effect on parasympathetic nerve activity during sleep. / Sagawa, Yohei; Kondo, Hideaki; Matsubuchi, Namiko; Takemura, Takaubu; Kanayama, Hironobu; Kaneko, Yoshihiko; Kanbayashi, Takashi; Hishikawa, Yasuo; Shimizu, Tetsuo.

In: Alcoholism: Clinical and Experimental Research, Vol. 35, No. 11, 01.11.2011, p. 2093-2100.

Research output: Contribution to journalArticle

Sagawa, Y, Kondo, H, Matsubuchi, N, Takemura, T, Kanayama, H, Kaneko, Y, Kanbayashi, T, Hishikawa, Y & Shimizu, T 2011, 'Alcohol has a dose-related effect on parasympathetic nerve activity during sleep', Alcoholism: Clinical and Experimental Research, vol. 35, no. 11, pp. 2093-2100. https://doi.org/10.1111/j.1530-0277.2011.01558.x
Sagawa, Yohei ; Kondo, Hideaki ; Matsubuchi, Namiko ; Takemura, Takaubu ; Kanayama, Hironobu ; Kaneko, Yoshihiko ; Kanbayashi, Takashi ; Hishikawa, Yasuo ; Shimizu, Tetsuo. / Alcohol has a dose-related effect on parasympathetic nerve activity during sleep. In: Alcoholism: Clinical and Experimental Research. 2011 ; Vol. 35, No. 11. pp. 2093-2100.
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