Alcohol-Induced Sinus Bradycardia and Hypotension in Patients with Syncope

Masato Tsutsui, Takeyuki Matsuguchi, Hiroyuki Tsutsui, Shingo Yoshihara, Kunihiko Yamamoto, Hiroaki Shimokawa, Shuichi Okamatsu, Ryuichi Hisanou, Tetsuhiko Yoshida

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


We observed 2 cases of repeated episodes of syncope after alcohol ingestion. Both patients were light drinkers and had carotid sinus hypersensitivity. In both cases, alcohol loading tests repeatedly induced sinus bradycardia and hypotension 1.0-1.5 hours after drinking alcohol. Atropine was effective in improving symptoms. A loading test using a glucose solution of equivalent osmolarity and volume was negative. Acute alcohol ingestion usually increases heart rate with variable effects on blood pressure. However, our 2 cases exhibited unusual alcohol-induced sinus bradycardia and hypotension, suggesting a paradoxical increase in parasympathetic activity and/or decrease in sympathetic activity.

Original languageEnglish
Pages (from-to)875-879
Number of pages5
Journaljapanese heart journal
Issue number6
Publication statusPublished - 1992
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


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