Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats

Tomoharu Masuda, Yasutoshi Hirabara, Yusuke Nakamura, Akiko Chishaki, Mai Tsuruhisa, Masayuki Miyakawa, Kenji Honda, Ryo Saito, Hirotaka Sakamoto, Mitsuhiro Kawata, Yukio Takano

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6 Citations (Scopus)

Abstract

We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium-loaded rats and was significantly reduced. This baroreflex sensi-tivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an impor-tant role in baroreflex function.

Original languageEnglish
Pages (from-to)482-486
Number of pages5
JournalJournal of Pharmacological Sciences
Volume112
Issue number4
DOIs
Publication statusPublished - Apr 16 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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    Masuda, T., Hirabara, Y., Nakamura, Y., Chishaki, A., Tsuruhisa, M., Miyakawa, M., Honda, K., Saito, R., Sakamoto, H., Kawata, M., & Takano, Y. (2010). Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats. Journal of Pharmacological Sciences, 112(4), 482-486. https://doi.org/10.1254/jphs.09362SC