Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid

Masao Yamasaki, Hitomi Chujo, Shinsuke Nou, Hirofumi Tachibana, Koji Yamada

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We showed the inhibitory effect of oleic and palmitoleic acids (OA and POA) on this trans10, cis12 (10t, 12c)-CLA induced cytotoxic activity. When cells were cultured in the presence of 10t, 12c-CLA, this potent cytotoxic effect on dRLh-84 cells was clearly obvious when compared to the control vehicle group. It was revealed that the levels of cellular OA and POA levels decreased upon cis9, trans11 (9c,11t) or 10t, 12c-CLA treatment in a time course dependent manner. OA or POA demonstrates a dose dependent inhibition of the 10t, 12c-CLA induced cytotoxicity. Notable nuclear fragmentation or activation of caspase-3 and 9 by 10t, 12c-CLA in dRLh-84 was counteracted by treatment with OA or POA. Results also suggest that 10t, 12c-CLA induced apoptosis can be inhibited by treatment with OA or POA.

Original languageEnglish
Pages (from-to)187-196
Number of pages10
JournalCancer Letters
Volume196
Issue number2
DOIs
Publication statusPublished - Jul 10 2003

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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