Allo-SCT using reduced-intensity conditioning against advanced pancreatic cancer: A Japanese survey

Y. Kanda, Y. Omuro, Eishi Baba, K. Oshima, K. Nagafuji, Y. Heike, Y. Takaue, T. Sasaki, H. Sakamaki, M. Harada

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Abstract

Pancreatic cancer is a frequent cause of cancer-related mortality and has an extremely poor prognosis. To evaluate the efficacy of allogeneic hematopoietic SCT with reduced-intensity conditioning (RICT) against pancreatic cancer, we analyzed the clinical data of 22 patients. After a fludarabine-based conditioning regimen followed by the infusion of PBSCs, all but two achieved engraftment. Complete, partial and minor response was observed in 1, 2 and 2 patients, respectively, with an overall response rate of 23%. Median survival was only 139 days and the major cause of death was tumor progression. Poor performance status before RICT and a lower number of infused CD34-positive cells were associated with shorter survival after RICT. Patients who developed chronic GVHD tended to survive longer than those who did not. These findings support the investigation of a novel treatment strategy to enhance the immunological effect against pancreatic cancer.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalBone Marrow Transplantation
Volume42
Issue number2
DOIs
Publication statusPublished - Jul 1 2008

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All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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