Allogeneic haematopoietic stem cell transplantation for infant acute lymphoblastic leukaemia with KMT2A (MLL) rearrangements: A retrospective study from the paediatric acute lymphoblastic leukaemia working group of the Japan Society for Haematopoietic Cell Transplantation

Motohiro Kato, Daiichiro Hasegawa, Katsuyoshi Koh, Keisuke Kato, Junko Takita, Jiro Inagaki, Hiromasa Yabe, Hiroaki Goto, Souichi Adachi, Akira Hayakawa, Yasufumi Takeshita, Akihisa Sawada, Yoshiko Atsuta, Koji Kato

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    Abstract

    Summary: Allogeneic haematopoietic stem cell transplantation (HSCT) is still considered to play an important role as a consolidation therapy for high-risk infants with acute lymphoblastic leukaemia (ALL). Here, we retrospectively analysed outcomes of HSCT in infants with ALL based on nationwide registry data of the Japan Society for Haematopoietic Cell Transplantation. A total of 132 allogeneic HSCT for infant ALL with KMT2A (MLL) gene rearrangements, which were performed in first complete remission (CR1), were analysed. The 5-year overall survival rate after transplantation was 67·4 ± 4·5%). Although recent HSCT (after 2004) had a trend toward better survival, no statistical correlation was observed between outcomes and each factor, including age at diagnosis, initial leucocyte count, cytogenetics, donor types or conditioning of HSCT. Myeloablative conditioning with total body irradiation did not provide a better survival (60·7 ± 9·2%) over that with busulfan (BU; 67·8 ± 5·7%). Two of the 28 patients treated with irradiation, but none of the 90 BU-treated patients, developed a secondary malignant neoplasm. In conclusion, allogeneic HSCT using BU was a valuable option for infant ALL with KMT2A rearrangements in CR1.

    Original languageEnglish
    Pages (from-to)564-570
    Number of pages7
    JournalBritish Journal of Haematology
    Volume168
    Issue number4
    DOIs
    Publication statusPublished - Feb 1 2015

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    All Science Journal Classification (ASJC) codes

    • Hematology

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