Allogeneic peripheral blood stem cell transplantation in 23 adult patients with hematologic malignancies: A single-center experience

Katsuto Takenaka, Katsuji Shinagawa, Kazutaka Sunami, Nobuharu Fujii, Yasushi Hiramatsu, Yoshinobu Maeda, Yuichiro Nawa, Yoshio Katayama, Takanori Teshima, Fumihiko Ishimaru, Katsuyuki Kiura, Kazuma Ikeda, Mine Harada

Research output: Contribution to journalArticle

Abstract

We describe a single-center experience of 23 consecutive patients (median age, 35 years) with hematologic malignancies who received allogeneic peripheral blood stem cell transplants (alloPBSCTs) from HLA-identical siblings. Ten patients had standard-risk disease and 13 had high-risk disease. Twenty-one patients received alloPBSCT as a primary transplant, and the remaining 2, with high-risk disease, as a second transplant after posttransplantation relapse. All donors received daily subcutaneous injections of granulocyte colony-stimulating factor at a dose of 10 μg/kg, and peripheral blood stem cells were collected by 1 to 3 aphereses. Median numbers of CD34+ and CD3+ cells infused were 5.8 × 106/kg (range, 1.3-19.7 × 106/kg) and 4.9 × 103/kg (range, 1.9-8.6 × 103/kg), respectively. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporin A (CyA) and methotrexate (18 patients) or CyA and methylprednisolone (5 patients). Rapid hematologic engraftment was observed in 20 of the 23 patients. Median days to absolute neutrophil counts >0.5 × 109/L and platelet counts >20 × 109/L were 12 (range, 9-18 days) and 14 (range, 10-128 days), respectively. Acute GVHD of grade 2-4 was observed in 6 of 20 evaluable patients (30%) and extensive chronic GVHD in 8 of 15 evaluable patients (53%).Ten of the 23 patients (44%) were surviving in continuous complete remission 191 to 1492 days (median, 643 days) posttransplantation. Treatment-related death within 100 days posttransplantation was observed in 6 of the 23 patients (26%). Six of the 23 patients (26%) developed relapse at a median 81 days (range, 38-160 days) posttransplantation. Further study is needed to assess the precise benefits of alloPBSCT compared with allogeneic bone marrow transplantation.

Original languageEnglish
Pages (from-to)362-370
Number of pages9
JournalInternational Journal of Hematology
Volume72
Issue number3
Publication statusPublished - Dec 1 2000

All Science Journal Classification (ASJC) codes

  • Hematology

Fingerprint Dive into the research topics of 'Allogeneic peripheral blood stem cell transplantation in 23 adult patients with hematologic malignancies: A single-center experience'. Together they form a unique fingerprint.

  • Cite this

    Takenaka, K., Shinagawa, K., Sunami, K., Fujii, N., Hiramatsu, Y., Maeda, Y., Nawa, Y., Katayama, Y., Teshima, T., Ishimaru, F., Kiura, K., Ikeda, K., & Harada, M. (2000). Allogeneic peripheral blood stem cell transplantation in 23 adult patients with hematologic malignancies: A single-center experience. International Journal of Hematology, 72(3), 362-370.