Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection

N. Fujii, Katsuto Takenaka, A. Hiraki, Y. Maeda, K. Ikeda, K. Shinagawa, A. Ashiba, M. Munemasa, K. Sunami, Y. Hiramatsu, F. Ishimaru, K. Niiya, T. Yoshino, M. Harada

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

Original languageEnglish
Pages (from-to)805-808
Number of pages4
JournalBone Marrow Transplantation
Volume26
Issue number7
Publication statusPublished - Nov 13 2000

Fingerprint

Peripheral Blood Stem Cell Transplantation
Epstein-Barr Virus Infections
Human Herpesvirus 4
Transplantation
Lymphocytes
Blood Cells
Liver
DNA
Natural Killer Cells
Therapeutics
Cell Proliferation
Hemorrhage
Drug Therapy
Polymerase Chain Reaction
Lung
Epstein-Barr virus encoded RNA 1

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Fujii, N., Takenaka, K., Hiraki, A., Maeda, Y., Ikeda, K., Shinagawa, K., ... Harada, M. (2000). Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection. Bone Marrow Transplantation, 26(7), 805-808.

Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection. / Fujii, N.; Takenaka, Katsuto; Hiraki, A.; Maeda, Y.; Ikeda, K.; Shinagawa, K.; Ashiba, A.; Munemasa, M.; Sunami, K.; Hiramatsu, Y.; Ishimaru, F.; Niiya, K.; Yoshino, T.; Harada, M.

In: Bone Marrow Transplantation, Vol. 26, No. 7, 13.11.2000, p. 805-808.

Research output: Contribution to journalArticle

Fujii, N, Takenaka, K, Hiraki, A, Maeda, Y, Ikeda, K, Shinagawa, K, Ashiba, A, Munemasa, M, Sunami, K, Hiramatsu, Y, Ishimaru, F, Niiya, K, Yoshino, T & Harada, M 2000, 'Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection', Bone Marrow Transplantation, vol. 26, no. 7, pp. 805-808.
Fujii N, Takenaka K, Hiraki A, Maeda Y, Ikeda K, Shinagawa K et al. Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection. Bone Marrow Transplantation. 2000 Nov 13;26(7):805-808.
Fujii, N. ; Takenaka, Katsuto ; Hiraki, A. ; Maeda, Y. ; Ikeda, K. ; Shinagawa, K. ; Ashiba, A. ; Munemasa, M. ; Sunami, K. ; Hiramatsu, Y. ; Ishimaru, F. ; Niiya, K. ; Yoshino, T. ; Harada, M. / Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection. In: Bone Marrow Transplantation. 2000 ; Vol. 26, No. 7. pp. 805-808.
@article{393aa580fd054c73bd17f187f82e9b8c,
title = "Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection",
abstract = "The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.",
author = "N. Fujii and Katsuto Takenaka and A. Hiraki and Y. Maeda and K. Ikeda and K. Shinagawa and A. Ashiba and M. Munemasa and K. Sunami and Y. Hiramatsu and F. Ishimaru and K. Niiya and T. Yoshino and M. Harada",
year = "2000",
month = "11",
day = "13",
language = "English",
volume = "26",
pages = "805--808",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Allogeneic peripheral blood stem celll transplantation for the treatment of chronic active Epstein-Barr virus infection

AU - Fujii, N.

AU - Takenaka, Katsuto

AU - Hiraki, A.

AU - Maeda, Y.

AU - Ikeda, K.

AU - Shinagawa, K.

AU - Ashiba, A.

AU - Munemasa, M.

AU - Sunami, K.

AU - Hiramatsu, Y.

AU - Ishimaru, F.

AU - Niiya, K.

AU - Yoshino, T.

AU - Harada, M.

PY - 2000/11/13

Y1 - 2000/11/13

N2 - The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

AB - The prognosis of chronic active Epstein-Barr virus infection (CAEBV) is very poor. We describe a 24-year-old male with severe CAEBV who was treated with allogeneic peripheral blood stem cell transplantation (allo-PBSCT). On admission, EBER-1 in lymphocytes infiltrating the liver, EBV-DNA in peripheral blood mononuclear cells (PBMC) and monoclonal NK cell proliferation were confirmed. After unsuccessful chemotherapy, he received an allo-PBSCT from his HLA-identical sister. Although he died of pulmonary hemorrhage on day +19, EBV-DNA was undetectable by PCR in PBMC, and the post-mortem liver showed no EBER-1-positive lymphocytes. This experience suggests that EBV-positive lymphocytes in CAEBV may be eradicated by allo-PBSCT, thereby raising the possibility of a new treatment modality.

UR - http://www.scopus.com/inward/record.url?scp=0033754421&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033754421&partnerID=8YFLogxK

M3 - Article

VL - 26

SP - 805

EP - 808

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

IS - 7

ER -