Allosteric binding of K+ to crown ether macrocycles appended to a lanthanum double decker system

Andrew Robertson, M. Ikeda, M. Takeuchi, Seiji Shinkai

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


A benzocrown-appended lanthanum(III) porphyrin double decker has been synthesized which is capable of binding simple K+ in a cooperative, allosteric fashion to form a 1:4 complex. Analysis of this system by means of the Hill equation gave an overall binding constant (Kb) of 1.0 × 1014 (mol dm-3)-4 and a Hill coefficient of 4.0. This same system, however, binds Na+ in a conventional, linear fashion. These results indicate that the novel allosteric binding occurs as the result of 1:2 sandwich complexes between K+ and appended crown ether moieties of the two joined porphyrins. The suitability of lanthanum(III) over cerium(IV) for preparing this highly crowded double decker porphyrin is also noted.

Original languageEnglish
Pages (from-to)883-888
Number of pages6
JournalBulletin of the Chemical Society of Japan
Issue number5
Publication statusPublished - May 1 2001

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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