Allosteric communication between the metal-binding lower rim and the sugar-binding upper rim on a calix[4]crown platform

Fumio Ohseto, Hiromasa Yamamoto, Hitoshi Matsumoto, Seiji Shinkai

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A calix[4]arene bearing two boronic acids on the upper rim and a crown loop on the lower rim was synthesized. This compound formed 1:1 complexes with D-glucose, D-talose, and D-allose and showed negative allosterism upon addition of Mg2+, Ca2+, Li+, or Na+, but positive allosterism upon addition of K+, Rb+, or Cs+. This is a novel example of allosteric 'communication' between metal ions and saccharides.

Original languageEnglish
Pages (from-to)6911-6914
Number of pages4
JournalTetrahedron Letters
Issue number38
Publication statusPublished - Sep 21 1995
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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