A calixarene bearing two boronic acids on the upper rim and a crown loop on the lower rim was synthesized. This compound formed 1:1 complexes with D-glucose, D-talose, and D-allose and showed negative allosterism upon addition of Mg2+, Ca2+, Li+, or Na+, but positive allosterism upon addition of K+, Rb+, or Cs+. This is a novel example of allosteric 'communication' between metal ions and saccharides.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry