Allosteric Interaction of Metal Ions with Saccharides in a Crowned Diboronic Acid

Gang Deng, Tony D. James, Seiji Shinkai

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

A diboronic acid saccharide (covalent) receptor site and a crown metal ion (electrostatic) receptor site are succesfully coupled in an allosteric system. The binding of monosaccharides with 2b as intramolecular 1:1 complexes was monitored by circular dichroism (CD). Added calcium perchlorate reduces the binding of the 1:1 saccharide complexes as followed by a decrease in the CD activity. This is a novel allosteric system which mimics the action of the Na+/D-glucose cotransport protein in nature.

Original languageEnglish
Pages (from-to)4567-4572
Number of pages6
JournalJournal of the American Chemical Society
Volume116
Issue number11
DOIs
Publication statusPublished - Jun 1 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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