ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE: IMMUNOLOGIC STUDIES

HIDEKI TESHIMA, ATSUMICHI URABE, MASAHIRO IRIE, TETSUYA NAKAGAWA, JUICHIRO NAKAYAMA, YOSHIAKI HORI

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Abstract

Alopecia universalis is a refractory condition. Although the cause of this disease is unknown, immunologic abnormalities have recently been suspected. Thus, we treated six cases of refractory alopecia universalis with immunotherapy. Oral administration of cyclosporine A (2.5 mg/kg) and prednisolone (5 mg/day) resulted in marked symptomatic improvement. Cyclosporine A did not produce any side effects because the administered dosage was relatively low. At present, more than 6 months after the cessation of treatment, recurrence of alopecia has not been seen. Oral administration of low‐dose cyclosporine A and prednisolone is considered to be an effective treatment for this disease. Immunologic examination of peripheral blood demonstrated improvement of immunologic function. In particular, cos‐positive T cells, NK cells, and C3, which had been reduced, were increased. A reduction in active CD4 cells, eosinophils, and circulating immune complexes was observed. Histology with fluorescent antibodies showed T‐cell infiltration around the hair matrixes. This phenomenon was no longer observed after treatment. These improvements in immunologic function were seen in parallel with the resolution of the clinical symptoms, indicating that immunologic abnormalities are related to this disease.

Original languageEnglish
Pages (from-to)513-516
Number of pages4
JournalInternational Journal of Dermatology
Volume31
Issue number7
DOIs
Publication statusPublished - Jul 1992

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Prednisolone
Cyclosporine
Oral Administration
Withholding Treatment
Alopecia
Antigen-Antibody Complex
Eosinophils
Natural Killer Cells
Immunotherapy
Histology
T-Lymphocytes
Recurrence
Antibodies
Therapeutics
Alopecia universalis

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE : IMMUNOLOGIC STUDIES. / TESHIMA, HIDEKI; URABE, ATSUMICHI; IRIE, MASAHIRO; NAKAGAWA, TETSUYA; NAKAYAMA, JUICHIRO; HORI, YOSHIAKI.

In: International Journal of Dermatology, Vol. 31, No. 7, 07.1992, p. 513-516.

Research output: Contribution to journalArticle

TESHIMA, HIDEKI, URABE, ATSUMICHI, IRIE, MASAHIRO, NAKAGAWA, TETSUYA, NAKAYAMA, JUICHIRO & HORI, YOSHIAKI 1992, 'ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE: IMMUNOLOGIC STUDIES', International Journal of Dermatology, vol. 31, no. 7, pp. 513-516. https://doi.org/10.1111/j.1365-4362.1992.tb02706.x
TESHIMA, HIDEKI ; URABE, ATSUMICHI ; IRIE, MASAHIRO ; NAKAGAWA, TETSUYA ; NAKAYAMA, JUICHIRO ; HORI, YOSHIAKI. / ALOPECIA UNIVERSALIS TREATED WITH ORAL CYCLOSPORINE A AND PREDNISOLONE : IMMUNOLOGIC STUDIES. In: International Journal of Dermatology. 1992 ; Vol. 31, No. 7. pp. 513-516.
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