Alteration of monoamine concentrations in the brain of medaka, Oryzias latipes, exposed to tributyltin

Kei Nakayama, Yuji Oshima, Tetsuya Tachibana, Mitsuhiro Furuse, Tsuneo Honjo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We measured the concentrations of monoamines in the brain of Japanese medaka, Oryzias latipes, exposed to tributyltin (TBT). Fish were exposed to 0, 1, 5, 25, or 125 μg g-1 of TBT via the diet for 21 days. After the administration period, six males and six females in each treatment group were dissected and their brains were collected. The following monoamines were analyzed: dopamine (DA), norepinephrine (NE), epinephrine (E), and 5-hydroxytryptamine (5-HT). The metabolites of DA, 3,4-dihydroxyphenylacetic acid and homovanilic acid, and the metabolite of 5-HT, 5-hydroxyindolacetic acid were also analyzed. The concentration of DA in the brain of male medaka and the concentrations of 5-HT and NE in the female brains were significantly decreased by exposure to 125 μg TBT g-1. The concentrations of 5-HT and NE in males and of DA in females were slightly decreased by 125 μg g -1 of TBT, although the differences were not statistically significant. The present study demonstrates that TBT alters monoamine concentrations in the brain of medaka.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalEnvironmental Toxicology
Volume22
Issue number1
DOIs
Publication statusPublished - Mar 1 2007

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Management, Monitoring, Policy and Law
  • Health, Toxicology and Mutagenesis

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