Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids

A. Morikawa, Kenji Hamase, T. Inoue, R. Konno, K. Zaitsu

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

To mutant ddY/DAO- mice lacking D-amino-acid oxidase activity and normal ddY/DAO+ mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pineal glands in both strains. In the ddY/DAO+ mice, the levels of the other D-amino acids did not significantly change in most of the brain regions. While in the ddY/DAO - mice the levels of D-Ser significantly increased in most of the brain regions except for the cerebrum and hippocampus. The levels of D-Ala and D-Leu increased in all regions but the levels of D-Pro did not significantly change. The same five D-amino acids were intravenously injected into Wistar rats and the D-amino acid levels in their brains were examined for 60 min after the administration. The levels of D-Asp markedly increased in the pineal gland 3 min after the administration, while the levels of D-Ser, D-Ala, and D-Pro increased both in the pineal and pituitary glands, the levels of D-Leu increased in all brain regions. These results are useful for the elucidation of the origins and regulation of D-amino acids in the mammalian body.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalAmino Acids
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 1 2007

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry
  • Endocrinology

Fingerprint Dive into the research topics of 'Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids'. Together they form a unique fingerprint.

Cite this