Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder

Mitsuru Kikuchi, Kiyomi Shitamichi, Yuko Yoshimura, Sanae Ueno, Hirotoshi Hiraishi, Tetsu Hirosawa, Toshio Munesue, Hideo Nakatani, Tsunehisa Tsubokawa, Yasuhiro Haruta, Manabu Oi, Yo Niida, Gerard Bastiaan Remijn, Tsutomu Takahashi, Michio Suzuki, Haruhiro Higashida, Yoshio Minabe

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Autism spectrum disorder (ASD) is often described as a disorder of aberrant neural connectivity and/or aberrant hemispheric lateralization. Although it is important to study the pathophysiology of the developing ASD cortex, the physiological connectivity of the brain in young children with ASD under conscious conditions has not yet been described. Magnetoencephalography (MEG) is a noninvasive brain imaging technique that is practical for use in young children. MEG produces a reference-free signal and is, therefore, an ideal tool for computing the coherence between two distant cortical rhythms. Using a custom child-sized MEG, we recently reported that 5- to 7-year-old children with ASD (n = 26) have inherently different neural pathways than typically developing (TD) children that contribute to their relatively preserved performance of visual tasks. In this study, we performed non-invasive measurements of the brain activity of 70 young children (3-7 years old, of which 18 were aged 3-4 years), a sample consisting of 35 ASD children and 35 TD children. Physiological connectivity and the laterality of physiological connectivity were assessed using intrahemispheric coherence for 9 frequency bands. As a result, significant rightward connectivity between the parietotemporal areas, via gamma band oscillations, was found in the ASD group. As we obtained the non-invasive measurements using a custom child-sized MEG, this is the first study to demonstrate a rightward-lateralized neurophysiological network in conscious young children (including children aged 3-4 years) with ASD.

Original languageEnglish
Pages (from-to)394-401
Number of pages8
JournalNeuroImage: Clinical
Volume2
Issue number1
DOIs
Publication statusPublished - Apr 11 2013

Fingerprint

Brain
Magnetoencephalography
Autism Spectrum Disorder
Neural Pathways
Task Performance and Analysis
Neuroimaging

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Kikuchi, M., Shitamichi, K., Yoshimura, Y., Ueno, S., Hiraishi, H., Hirosawa, T., ... Minabe, Y. (2013). Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder. NeuroImage: Clinical, 2(1), 394-401. https://doi.org/10.1016/j.nicl.2013.03.003

Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder. / Kikuchi, Mitsuru; Shitamichi, Kiyomi; Yoshimura, Yuko; Ueno, Sanae; Hiraishi, Hirotoshi; Hirosawa, Tetsu; Munesue, Toshio; Nakatani, Hideo; Tsubokawa, Tsunehisa; Haruta, Yasuhiro; Oi, Manabu; Niida, Yo; Remijn, Gerard Bastiaan; Takahashi, Tsutomu; Suzuki, Michio; Higashida, Haruhiro; Minabe, Yoshio.

In: NeuroImage: Clinical, Vol. 2, No. 1, 11.04.2013, p. 394-401.

Research output: Contribution to journalArticle

Kikuchi, M, Shitamichi, K, Yoshimura, Y, Ueno, S, Hiraishi, H, Hirosawa, T, Munesue, T, Nakatani, H, Tsubokawa, T, Haruta, Y, Oi, M, Niida, Y, Remijn, GB, Takahashi, T, Suzuki, M, Higashida, H & Minabe, Y 2013, 'Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder', NeuroImage: Clinical, vol. 2, no. 1, pp. 394-401. https://doi.org/10.1016/j.nicl.2013.03.003
Kikuchi M, Shitamichi K, Yoshimura Y, Ueno S, Hiraishi H, Hirosawa T et al. Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder. NeuroImage: Clinical. 2013 Apr 11;2(1):394-401. https://doi.org/10.1016/j.nicl.2013.03.003
Kikuchi, Mitsuru ; Shitamichi, Kiyomi ; Yoshimura, Yuko ; Ueno, Sanae ; Hiraishi, Hirotoshi ; Hirosawa, Tetsu ; Munesue, Toshio ; Nakatani, Hideo ; Tsubokawa, Tsunehisa ; Haruta, Yasuhiro ; Oi, Manabu ; Niida, Yo ; Remijn, Gerard Bastiaan ; Takahashi, Tsutomu ; Suzuki, Michio ; Higashida, Haruhiro ; Minabe, Yoshio. / Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder. In: NeuroImage: Clinical. 2013 ; Vol. 2, No. 1. pp. 394-401.
@article{58a6b0935c884119a153e59d05df0ee8,
title = "Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder",
abstract = "Autism spectrum disorder (ASD) is often described as a disorder of aberrant neural connectivity and/or aberrant hemispheric lateralization. Although it is important to study the pathophysiology of the developing ASD cortex, the physiological connectivity of the brain in young children with ASD under conscious conditions has not yet been described. Magnetoencephalography (MEG) is a noninvasive brain imaging technique that is practical for use in young children. MEG produces a reference-free signal and is, therefore, an ideal tool for computing the coherence between two distant cortical rhythms. Using a custom child-sized MEG, we recently reported that 5- to 7-year-old children with ASD (n = 26) have inherently different neural pathways than typically developing (TD) children that contribute to their relatively preserved performance of visual tasks. In this study, we performed non-invasive measurements of the brain activity of 70 young children (3-7 years old, of which 18 were aged 3-4 years), a sample consisting of 35 ASD children and 35 TD children. Physiological connectivity and the laterality of physiological connectivity were assessed using intrahemispheric coherence for 9 frequency bands. As a result, significant rightward connectivity between the parietotemporal areas, via gamma band oscillations, was found in the ASD group. As we obtained the non-invasive measurements using a custom child-sized MEG, this is the first study to demonstrate a rightward-lateralized neurophysiological network in conscious young children (including children aged 3-4 years) with ASD.",
author = "Mitsuru Kikuchi and Kiyomi Shitamichi and Yuko Yoshimura and Sanae Ueno and Hirotoshi Hiraishi and Tetsu Hirosawa and Toshio Munesue and Hideo Nakatani and Tsunehisa Tsubokawa and Yasuhiro Haruta and Manabu Oi and Yo Niida and Remijn, {Gerard Bastiaan} and Tsutomu Takahashi and Michio Suzuki and Haruhiro Higashida and Yoshio Minabe",
year = "2013",
month = "4",
day = "11",
doi = "10.1016/j.nicl.2013.03.003",
language = "English",
volume = "2",
pages = "394--401",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Altered brain connectivity in 3-to 7-year-old children with autism spectrum disorder

AU - Kikuchi, Mitsuru

AU - Shitamichi, Kiyomi

AU - Yoshimura, Yuko

AU - Ueno, Sanae

AU - Hiraishi, Hirotoshi

AU - Hirosawa, Tetsu

AU - Munesue, Toshio

AU - Nakatani, Hideo

AU - Tsubokawa, Tsunehisa

AU - Haruta, Yasuhiro

AU - Oi, Manabu

AU - Niida, Yo

AU - Remijn, Gerard Bastiaan

AU - Takahashi, Tsutomu

AU - Suzuki, Michio

AU - Higashida, Haruhiro

AU - Minabe, Yoshio

PY - 2013/4/11

Y1 - 2013/4/11

N2 - Autism spectrum disorder (ASD) is often described as a disorder of aberrant neural connectivity and/or aberrant hemispheric lateralization. Although it is important to study the pathophysiology of the developing ASD cortex, the physiological connectivity of the brain in young children with ASD under conscious conditions has not yet been described. Magnetoencephalography (MEG) is a noninvasive brain imaging technique that is practical for use in young children. MEG produces a reference-free signal and is, therefore, an ideal tool for computing the coherence between two distant cortical rhythms. Using a custom child-sized MEG, we recently reported that 5- to 7-year-old children with ASD (n = 26) have inherently different neural pathways than typically developing (TD) children that contribute to their relatively preserved performance of visual tasks. In this study, we performed non-invasive measurements of the brain activity of 70 young children (3-7 years old, of which 18 were aged 3-4 years), a sample consisting of 35 ASD children and 35 TD children. Physiological connectivity and the laterality of physiological connectivity were assessed using intrahemispheric coherence for 9 frequency bands. As a result, significant rightward connectivity between the parietotemporal areas, via gamma band oscillations, was found in the ASD group. As we obtained the non-invasive measurements using a custom child-sized MEG, this is the first study to demonstrate a rightward-lateralized neurophysiological network in conscious young children (including children aged 3-4 years) with ASD.

AB - Autism spectrum disorder (ASD) is often described as a disorder of aberrant neural connectivity and/or aberrant hemispheric lateralization. Although it is important to study the pathophysiology of the developing ASD cortex, the physiological connectivity of the brain in young children with ASD under conscious conditions has not yet been described. Magnetoencephalography (MEG) is a noninvasive brain imaging technique that is practical for use in young children. MEG produces a reference-free signal and is, therefore, an ideal tool for computing the coherence between two distant cortical rhythms. Using a custom child-sized MEG, we recently reported that 5- to 7-year-old children with ASD (n = 26) have inherently different neural pathways than typically developing (TD) children that contribute to their relatively preserved performance of visual tasks. In this study, we performed non-invasive measurements of the brain activity of 70 young children (3-7 years old, of which 18 were aged 3-4 years), a sample consisting of 35 ASD children and 35 TD children. Physiological connectivity and the laterality of physiological connectivity were assessed using intrahemispheric coherence for 9 frequency bands. As a result, significant rightward connectivity between the parietotemporal areas, via gamma band oscillations, was found in the ASD group. As we obtained the non-invasive measurements using a custom child-sized MEG, this is the first study to demonstrate a rightward-lateralized neurophysiological network in conscious young children (including children aged 3-4 years) with ASD.

UR - http://www.scopus.com/inward/record.url?scp=84875902237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875902237&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2013.03.003

DO - 10.1016/j.nicl.2013.03.003

M3 - Article

VL - 2

SP - 394

EP - 401

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

IS - 1

ER -