Altered cerebrovascular response to a potassium channel opener in hypertensive rats

Hitonori Takaba, Tetsuhiko Nagao, Setsuro Ibayashi, Takanari Kitazono, Kenichiro Fujii, Masatoshi Fujishima

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We examined whether the effect of Y-26763, an ATP-sensitive potassium channel opener, on cerebral blood flow is altered in stroke prone spontaneously hypertensive rats (SHRSP) and, if altered, whether long-term antihypertensive treatment with cilazapril, an angiotensin-converting enzyme inhibitor, is capable of preventing the change. Cerebral blood flow during intracarotid infusion of Y-26763 was measured in anesthetized SHRSP and normotensive Wistar-Kyoto rats (WKY) as control. Y-26763 increased cerebral blood flow in a dose-dependent manner in WKY, and glibenclamide, a selective inhibitor of ATP-sensitive potassium channels, inhibited the Y-26763-induced increase in cerebral blood flow. In contrast, the response to Y-26763 in SHRSP was significantly impaired compared with that in WKY. Antihypertensive treatment with cilazapril lowered blood pressure toward normal and prevented the impaired response in cerebral blood flow to Y-26763 in SHRSP. These findings suggest that (1) ATP-sensitive potassium channels contribute to the regulation of cerebral blood flow in rats, (2) the response to an ATP- sensitive potassium channel opener is markedly diminished in hypertensive rats, and (3) the altered response to an ATP-sensitive potassium channel opener during chronic hypertension can be prevented by long-term antihypertensive treatment.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalHypertension
Volume28
Issue number1
DOIs
Publication statusPublished - Jan 1 1996

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Cerebrovascular Circulation
Potassium Channels
KATP Channels
Inbred WKY Rats
Cilazapril
Antihypertensive Agents
Glyburide
Inbred SHR Rats
Angiotensin-Converting Enzyme Inhibitors
Y 26763
Stroke
Blood Pressure
Hypertension

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Altered cerebrovascular response to a potassium channel opener in hypertensive rats. / Takaba, Hitonori; Nagao, Tetsuhiko; Ibayashi, Setsuro; Kitazono, Takanari; Fujii, Kenichiro; Fujishima, Masatoshi.

In: Hypertension, Vol. 28, No. 1, 01.01.1996, p. 143-146.

Research output: Contribution to journalArticle

Takaba, H, Nagao, T, Ibayashi, S, Kitazono, T, Fujii, K & Fujishima, M 1996, 'Altered cerebrovascular response to a potassium channel opener in hypertensive rats', Hypertension, vol. 28, no. 1, pp. 143-146. https://doi.org/10.1161/01.HYP.28.1.143
Takaba, Hitonori ; Nagao, Tetsuhiko ; Ibayashi, Setsuro ; Kitazono, Takanari ; Fujii, Kenichiro ; Fujishima, Masatoshi. / Altered cerebrovascular response to a potassium channel opener in hypertensive rats. In: Hypertension. 1996 ; Vol. 28, No. 1. pp. 143-146.
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