Abstract
Background: It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In addition, it has been suggested that alterations in the balance of polyunsaturated fatty acids are associated with brain dysfunctions such as neurodegerative pathologies of the aging brain. Method: To explore COX-2 expression in the hippocampus, we analyzed 45 consecutive autopsy subjects without dementia and 25 AD patients derived from the town of Hisayama, Japan. Results: The neuronal expression of COX-2 in the CA3 subdivision of the hippocampus, subiculum, entorhinal cortex and transentorhinal cortex were consistently observed in both nondemented and AD brains, and COX-2 immunoreactivity correlated with age in nondemented brains. In AD patients, neurons of CA1 exhibited increased COX-2 immunoreactivity which correlated with the severity of AD pathology. This correlation was not apparent in nondemented subjects. Conclusion: These results suggest that COX-2 expression may be differentially regulated among subdivisions of the hippocampus and that elevated COX-2 expression in the CA1 of AD brains may be associated with AD pathology and thus cognitive dysfunction.
| Original language | English |
|---|---|
| Pages (from-to) | 423-431 |
| Number of pages | 9 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 23 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - May 1 2007 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Geriatrics and Gerontology
- Cognitive Neuroscience
- Psychiatry and Mental health
Cite this
Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease : The Hisayama study. / Fujimi, Kouhei; Noda, Kazuhito; Sasaki, Kensuke; Wakisaka, Yoshinobu; Tanizaki, Yumihiro; Iida, Mitsuo; Kiyohara, Yutaka; Kanba, Shigenobu; Iwaki, Toru.
In: Dementia and Geriatric Cognitive Disorders, Vol. 23, No. 6, 01.05.2007, p. 423-431.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Altered expression of COX-2 in subdivisions of the hippocampus during aging and in Alzheimer's disease
T2 - The Hisayama study
AU - Fujimi, Kouhei
AU - Noda, Kazuhito
AU - Sasaki, Kensuke
AU - Wakisaka, Yoshinobu
AU - Tanizaki, Yumihiro
AU - Iida, Mitsuo
AU - Kiyohara, Yutaka
AU - Kanba, Shigenobu
AU - Iwaki, Toru
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Background: It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In addition, it has been suggested that alterations in the balance of polyunsaturated fatty acids are associated with brain dysfunctions such as neurodegerative pathologies of the aging brain. Method: To explore COX-2 expression in the hippocampus, we analyzed 45 consecutive autopsy subjects without dementia and 25 AD patients derived from the town of Hisayama, Japan. Results: The neuronal expression of COX-2 in the CA3 subdivision of the hippocampus, subiculum, entorhinal cortex and transentorhinal cortex were consistently observed in both nondemented and AD brains, and COX-2 immunoreactivity correlated with age in nondemented brains. In AD patients, neurons of CA1 exhibited increased COX-2 immunoreactivity which correlated with the severity of AD pathology. This correlation was not apparent in nondemented subjects. Conclusion: These results suggest that COX-2 expression may be differentially regulated among subdivisions of the hippocampus and that elevated COX-2 expression in the CA1 of AD brains may be associated with AD pathology and thus cognitive dysfunction.
AB - Background: It has been reported that nonsteroidal anti-inflammatory drugs may delay the onset of Alzheimer's disease (AD). Since nonsteroidal anti-inflammatory drugs inhibit cyclooxygenase (COX), COX-2, an inducible form of COX, may be involved in the pathology of AD in association with the arachidonic acid cascade. In addition, it has been suggested that alterations in the balance of polyunsaturated fatty acids are associated with brain dysfunctions such as neurodegerative pathologies of the aging brain. Method: To explore COX-2 expression in the hippocampus, we analyzed 45 consecutive autopsy subjects without dementia and 25 AD patients derived from the town of Hisayama, Japan. Results: The neuronal expression of COX-2 in the CA3 subdivision of the hippocampus, subiculum, entorhinal cortex and transentorhinal cortex were consistently observed in both nondemented and AD brains, and COX-2 immunoreactivity correlated with age in nondemented brains. In AD patients, neurons of CA1 exhibited increased COX-2 immunoreactivity which correlated with the severity of AD pathology. This correlation was not apparent in nondemented subjects. Conclusion: These results suggest that COX-2 expression may be differentially regulated among subdivisions of the hippocampus and that elevated COX-2 expression in the CA1 of AD brains may be associated with AD pathology and thus cognitive dysfunction.
UR - http://www.scopus.com/inward/record.url?scp=34250221511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250221511&partnerID=8YFLogxK
U2 - 10.1159/000101957
DO - 10.1159/000101957
M3 - Article
C2 - 17457030
AN - SCOPUS:34250221511
VL - 23
SP - 423
EP - 431
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 6
ER -