Altered nociceptive response in ADAM11-deficient mice

Eiki Takahashi, Koji Sagane, Takeshi Nagasu, Junro Kuromitsu

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Mice that lack A Disintegrin And Metalloprotease 11 (ADAM11) protein showed normal responses to stimuli in the von Frey test and the hot plate test, but showed reduced responses in the formalin paw test and acetic acid writhing test. Our results indicate that the cell adhesion-related molecule ADAM11 may play a role in pain transmission and in inflammatory regulation mechanisms underlying changes in the threshold for pain perception.

Original languageEnglish
Pages (from-to)39-42
Number of pages4
JournalBrain Research
Volume1097
Issue number1
DOIs
Publication statusPublished - Jun 30 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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