[Amebic colitis and liver abscess complicated by high serum procalcitonin in acute myeloid leukemia].

Eijiro Oku, Kei Nomura, Takayuki Nakamura, Satoshi Morishige, Ritsuko Seki, Rie Imamura, Michitoshi Hashiguchi, Kouichi Osaki, Shinichi Mizuno, Koji Nagafuji, Takashi Okamura

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Abstract

We present a case of amebic colitis and liver abscess complicated by acute myeloid leukemia (AML) with high serum procalcitonin (PCT). A 61-year-old Japanese man seen at our hospital for severe diarrhea and high fever was found to have multiple ulcers in the transverse and sigmoid colon and rectum by colonoscopy and biopsies were conducted. Immature leukocytes with mild anemia and thrombocytopenia were seen in peripheral blood, necessitating bone marrow aspiration and biopsy that yielded a diagnosis of AML (FAB M4Eo). Serum C-reactive protein and PCT were extremely elevated. Blood cultures for bacteria and fungi were negative. Multiple low-density areas in the liver were found in abdominal computed tomography. Histological colon biopsy findings revealed amebic colitis, strongly suggesting amebic liver abscess. Metronidazole treatment was initiated for amebiasis and subsequent standard chemotherapy for AML was followed after fever was lowered. Hematological and cytogenetic CR was maintained with good clinical condition. Few case reports have been published in Japan to date on amebic colitis and liver abscess complicated by AML and no reports have been made on PCT elevation caused by amebiasis. In conclusion, differential diagnosis of amebiasis is necessary in addition to that of bacterial or fungal infection in serum PCT elevation.

Original languageEnglish
Pages (from-to)773-777
Number of pages5
JournalUnknown Journal
Volume86
Issue number6
DOIs
Publication statusPublished - Nov 2012

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Oku, E., Nomura, K., Nakamura, T., Morishige, S., Seki, R., Imamura, R., Hashiguchi, M., Osaki, K., Mizuno, S., Nagafuji, K., & Okamura, T. (2012). [Amebic colitis and liver abscess complicated by high serum procalcitonin in acute myeloid leukemia]. Unknown Journal, 86(6), 773-777. https://doi.org/10.11150/kansenshogakuzasshi.86.773