Amelioration of delayed-type hypersensitivity responses by IL-27 administration

Yoshiyuki Miyazaki, Yohei Shimanoe, Seng Wang, Hiroki Yoshida

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor α chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Here we investigated the effect of IL-27 administration on delayed-type hypersensitivity (DTH). While WSX-1-deficient mice showed higher DTH responses as shown by the degree of footpad swelling, administration of IL-27 significantly ameliorated the footpad swelling. Since the activation status of the draining lymph node cells were not affected by IL-27 deficiency, it was suggested that IL-27 affected the effector phase of the response. These results collectively indicate that IL-27 has a suppressive effect on activated T cells in the experimental model and also has a therapeutic potential for some diseases caused by immune disorder.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume373
Issue number3
DOIs
Publication statusPublished - Aug 29 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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