Amelioration of extrapontine myelinolysis and reversible Parkinsonism in a patient with asymptomatic hypopituitarism

Kyoko Okada, Masatoshi Nomura, Norihiro Furusyo, Shigeru Otaguro, Shigeki Nabeshima, Jun Hayashi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A 37-year-old woman with a history of transphenoidal surgery and gamma knife treatment for prolactinoma was admitted because of pneumoniae with hyponatremia (Na 109 mmol/l). After the careful correction of the serum sodium level within 15 mmol/l/day, the patient developed parkinsonism. MRI of the brain disclosed a signal increase in the bilateral basal ganglias on T2-weighted images, a finding consistent with extrapontine myelinolysis (EPM). Interestingly, the parkinsonism fully disappeared after the replacement therapy of hydrocortisone for adrenal insufficiency due to hypopituitarism, and MRI 5 months later showed complete disappearance of the lesions, indicating the patient had ameliorated from the EPM.

Original languageEnglish
Pages (from-to)739-742
Number of pages4
JournalInternal Medicine
Volume44
Issue number7
DOIs
Publication statusPublished - Jul 1 2005

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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